Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
J ECT. 2013 Mar;29(1):67-74. doi: 10.1097/YCT.0b013e318270295f.
Despite the development of second-generation antipsychotic drugs, treatment-resistant symptoms still represent a serious problem in schizophrenia. The aim of the present article was to review studies with repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia and draw conclusions for clinical decision making.
Literature for this review was identified by searching MEDLINE and ISI Web of Science up to the year 2011.
Five open studies, 13 sham-controlled studies, and 2 meta-analysis and 2 review articles were included in the present paper. The effect size of the high frequency repetitive transcranial magnetic stimulation (rTMS) over the left prefrontal cortex in the treatment of negative symptoms of schizophrenia is thought to be mild to moderate (Cohen d = 0.43-0.68).
Despite the promising results of some rTMS studies, the potential of rTMS for the treatment of negative symptoms is currently relatively unclear. Large clinical studies are therefore needed, especially large multicentric studies such as depression rTMS studies.
尽管第二代抗精神病药物已经发展，但是治疗抵抗症状仍然是精神分裂症的一个严重问题。本文的目的是回顾重复经颅磁刺激治疗精神分裂症阴性症状的研究，并为临床决策提供结论。
通过检索 MEDLINE 和 ISI Web of Science，本文对截至 2011 年的文献进行了回顾。
本文纳入了 5 项开放研究、13 项假刺激对照研究、2 项荟萃分析和 2 篇综述文章。高频重复经颅磁刺激（rTMS）治疗精神分裂症阴性症状的效应大小被认为是轻度到中度（Cohen d = 0.43-0.68）。
尽管一些 rTMS 研究结果有前景，但 rTMS 治疗阴性症状的潜力目前尚不清楚。因此，需要进行大型临床研究，特别是像抑郁症 rTMS 研究这样的大型多中心研究。
