Girardi C, Re G, Farca A M, Dacasto M, Ferrero E, Eandi M
Dipartimento di Patologia Animale, Università di Torino, Italia.
Pharmacol Res. 1990 Mar-Apr;22(2):79-86. doi: 10.1016/1043-6618(90)90703-g.
Intrauterine administration was performed in six Friesan cows with a disposable spray preparation containing 3 g of sulfamonomethoxine and 3 g of oxytetracycline, in order to investigate their serum kinetics. Sulfamonomethoxine levels were determined by a reversed-phase HPLC method, whilst oxytetracycline quantities were detected by a microbiological method. The sulphonamide had a peak 1.17 h after the administration, the tetracycline reached its highest concentration after 8 h. The bioavailability of both drugs was low and detectable drug amounts were no longer recovered after 24 h.
为了研究其血清动力学，对6头弗里斯兰奶牛进行了宫内给药，使用一种含有3克磺胺间甲氧嘧啶和3克土霉素的一次性喷雾制剂。磺胺间甲氧嘧啶水平通过反相高效液相色谱法测定，而土霉素含量通过微生物学方法检测。磺胺类药物在给药后1.17小时达到峰值，四环素在8小时后达到最高浓度。两种药物的生物利用度都很低，24小时后不再能检测到药物量。
