Sharma Jyoti, Brunson Jonathan Matthew, Memon Nada, Khakoo Aarif Y
Division of Cardiology, Department of Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas 77054, USA.
Tex Heart Inst J. 2012;39(6):890-3.
A 41-year-old woman with metastatic melanoma was admitted to the hospital because of syncopal episodes, which had developed after the administration of an experimental chemotherapy agent that targeted Notch signaling, as part of a phase I clinical trial. Cardiac monitoring revealed recurrent episodes of polymorphic ventricular tachycardia correlating with the patient's syncope. Investigations into the cause of the arrhythmia led to the discovery of metastatic lesions within the left ventricular myocardium. In presenting this case of polymorphic ventricular tachycardia as the antemortem clinical manifestation of metastatic melanoma involving the heart, we discuss the importance of recognizing that cardiac metastases can manifest themselves as arrhythmias in patients with malignant melanoma who are undergoing active anticancer treatment.
一名41岁的转移性黑色素瘤女性患者因晕厥发作入院，这些晕厥发作是在作为一项I期临床试验的一部分，给予一种靶向Notch信号通路的实验性化疗药物后出现的。心脏监测显示多形性室性心动过速反复发作，与患者的晕厥相关。对心律失常原因的调查发现左心室心肌内有转移病灶。在将这例多形性室性心动过速作为转移性黑色素瘤累及心脏的死前临床表现进行介绍时，我们讨论了认识到心脏转移在接受积极抗癌治疗的恶性黑色素瘤患者中可表现为心律失常的重要性。
