Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
Mediators Inflamm. 2012;2012:979105. doi: 10.1155/2012/979105. Epub 2012 Dec 6.
Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease. Recently, an increasing number of studies have focused on inflammatory diseases. TBK1 is a serine/threonine-protein kinase which regulates antiviral defense, host-virus interaction, and immunity. It is ubiquitously expressed in mouse stomach, colon, thymus, and liver. Interestingly, high levels of active TBK1 have also been found to be associated with inflammatory diseases, indicating that TBK1 is closely related to inflammatory responses. Even though relatively few studies have addressed the functional roles of TBK1 relating to inflammation, this paper discusses some recent findings that support the critical role of TBK1 in inflammatory diseases and underlie the necessity of trials to develop useful remedies or therapeutics that target TBK1 for the treatment of inflammatory diseases.
炎症是组织对有害刺激（如病原体、细胞损伤或刺激物）的复杂生物学反应。炎症被认为是大多数慢性疾病的主要原因，特别是在 100 多种炎症性疾病中，包括阿尔茨海默病、类风湿性关节炎、哮喘、动脉粥样硬化、克罗恩病、结肠炎、皮炎、肝炎和帕金森病。最近，越来越多的研究集中在炎症性疾病上。TBK1 是一种丝氨酸/苏氨酸蛋白激酶，可调节抗病毒防御、宿主-病毒相互作用和免疫。它在小鼠的胃、结肠、胸腺和肝脏中广泛表达。有趣的是，高水平的活性 TBK1 也与炎症性疾病有关，表明 TBK1 与炎症反应密切相关。尽管相对较少的研究探讨了 TBK1 与炎症相关的功能作用，但本文讨论了一些支持 TBK1 在炎症性疾病中起关键作用的最新发现，并强调了开发针对 TBK1 的有用治疗方法或疗法的必要性，以治疗炎症性疾病。
