菖蒲叶精油的双重抗黑色素生成和抗氧化活性。
The Dual Antimelanogenic and Antioxidant Activities of the Essential Oil Extracted from the Leaves of Acorus macrospadiceus (Yamamoto) F. N. Wei et Y. K. Li.
机构信息
Department of Medical Laboratory Science and Biotechnology, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.
出版信息
Evid Based Complement Alternat Med. 2012;2012:781280. doi: 10.1155/2012/781280. Epub 2012 Oct 31.
The antimelanogenic and antioxidant activities of the essential oil extracted from the leaves of Acorus macrospadiceus (Yamamoto) F. N. Wei et Y. K. Li have never been explored. The essential oil effectively inhibited mushroom tyrosinase activity (EC(50) = 1.57 mg/mL) and B16F10 tyrosinase activity (IC(50) = 1.01 mg/mL), decreased the melanin content (EC(50) = 1.04 mg/mL), and depleted the cellular level of the reactive oxygen species (ROS) (EC(50) = 1.87 mg/mL). The essential oil effectively scavenged 2,2-diphenyl-1-picryl-hydrazyl (DPPH) (EC(50) = 0.121 mg/mL) and 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) ABTS(+) radicals (EC(50) = 0.122 mg/mL). It also exhibited an apparent reducing power (EC(50) = 0.021 mg/mL) and metal-ion chelating activity (EC(50) = 0.029 mg/mL). The chemical constituents of the essential oil are ethers (55.73%), ketones (19.57%), monoterpenes (7.82%), alcohols (3.85%), esters (3.77%), sesquiterpenes (3.72%), and aromatic compounds (2.85%). The results confirm that A. macrospadiceus essential oil is a natural antioxidant and inhibitor of melanogenesis.
菖蒲叶精油的抗黑色素生成和抗氧化活性尚未被研究过。该精油有效抑制了蘑菇酪氨酸酶活性（EC50 = 1.57mg/mL）和 B16F10 酪氨酸酶活性（IC50 = 1.01mg/mL），降低了黑色素含量（EC50 = 1.04mg/mL），并耗竭了细胞内活性氧物种（ROS）的水平（EC50 = 1.87mg/mL）。该精油有效清除了 2,2-二苯基-1-苦基肼基（DPPH）（EC50 = 0.121mg/mL）和 2,2'-联氮-双（3-乙基苯并噻唑啉-6-磺酸）ABTS（+）自由基（EC50 = 0.122mg/mL）。它还表现出明显的还原能力（EC50 = 0.021mg/mL）和金属离子螯合活性（EC50 = 0.029mg/mL）。精油的化学成分包括醚类（55.73%）、酮类（19.57%）、单萜类（7.82%）、醇类（3.85%）、酯类（3.77%）、倍半萜类（3.72%）和芳香族化合物（2.85%）。结果证实，菖蒲叶精油是一种天然的抗氧化剂和黑色素生成抑制剂。
Zotero 插件