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经支气管镜置入硅酮气管支架治疗复杂良性气管切开后气管狭窄,适用于气管重建手术失败或禁忌的患者。

Management of complex benign post-tracheostomy tracheal stenosis with bronchoscopic insertion of silicon tracheal stents, in patients with failed or contraindicated surgical reconstruction of trachea.

机构信息

Cardiothoracic Department, St Luke's Hospital, Panorama, Thessaloniki, Greece;

出版信息

J Thorac Dis. 2012 Nov;4 Suppl 1(Suppl 1):32-40. doi: 10.3978/j.issn.2072-1439.2012.s002.

Abstract

Tracheal stenosis is a potentially life-threatening condition. Tracheostomy and endotracheal intubation remain the commonest causes of benign stenosis, despite improvements in design and management of tubes. Post-tracheostomy stenosis is more frequently encountered due to earlier performance of tracheostomy in the intensive care units, while the incidence of post-intubation stenosis has decreased with application of high-volume, low-pressure cuffs. In symptomatic benign tracheal stenosis the gold standard is surgical reconstruction (often after interventional bronchoscopy). Stenting is reserved for symptomatic tracheal narrowing deemed inoperable, due to local or general reasons: long strictures, inflammation, poor respiratory, cardiac or neurological status. When stenting is decided, silicone stent insertion is considered the treatment of choice in the presence of inflammation and/or when removal is desirable. We inserted tracheal silicone stents (Dumon) under general anaesthesia through rigid bronchoscopy in two patients with benign post-tracheostomy stenosis: a 39-year old woman with failed initial operation, and continuous relapses with proliferation after multiple bronchscopic interventions, and a 20-year old man in a poor neurological status, with a long tracheal stricture involving the subglottic larynx (lower posterior part), and inflamed tracheostomy site tissues (positive for methicillin resistant staphylococcus aureus). The airway was immediately re-establish, without complications. At 15- and 10-month follow-up (respectively) there was no stent migration, luminal patency was maintained without: adjacent structure erosion, secretion adherence inside the stents, granulation at the ends. Tracheostomy tissue inflammation was resolved (2(nd) patient), new infection was not noted. The patients maintain good respiratory function and will be evaluated for scheduled stent removal. Silicone stents are removable, resistant to microbial colonization and are associated with minimal granulation. In benign post-tracheostomy stenosis silicone stenting appeared safe and effective in re-stenosis after surgery and multiple bronchoscopic interventions, and in long stenosis, involving the lower posterior subglottic larynx in the presence on inflammation and poor neurological status.

摘要

气管狭窄是一种潜在的危及生命的疾病。尽管在管设计和管理方面有所改进,但气管切开术和气管内插管仍然是良性狭窄最常见的原因。由于在重症监护病房中更早地进行气管切开术,因此更常发生气管切开术后狭窄,而由于高容量、低压力袖带的应用,插管后狭窄的发生率有所下降。在有症状的良性气管狭窄中,金标准是手术重建(通常在介入性支气管镜检查之后)。支架置入术保留用于因局部或全身原因而认为不可手术的有症状的气管狭窄:长段狭窄、炎症、呼吸、心脏或神经状态不佳。当决定支架置入时,如果存在炎症和/或需要移除时,会考虑插入硅酮支架。我们通过硬质支气管镜在两名良性气管切开术后狭窄患者中插入气管硅酮支架(Dumon):一名 39 岁女性,初始手术失败,且在多次支气管镜介入治疗后出现增殖性复发;一名 20 岁男性,神经状态不佳,长段气管狭窄累及声门下喉(下后部分)和炎症性气管造口部位组织(耐甲氧西林金黄色葡萄球菌阳性)。气道立即重建,无并发症。在 15 个月和 10 个月的随访中(分别),支架没有移位,管腔通畅,没有:相邻结构侵蚀、支架内分泌物附着、末端肉芽组织形成。气管切开术组织炎症得到缓解(第 2 例患者),未出现新感染。患者保持良好的呼吸功能,将对预定的支架移除进行评估。硅酮支架可移除,不易受微生物定植,且与最小的肉芽组织形成有关。在良性气管切开术后狭窄中,在手术后和多次支气管镜介入治疗后再狭窄以及在存在炎症和神经状态不佳的情况下累及下后声门下喉的长段狭窄中,硅酮支架置入术似乎是安全有效的。

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