Wong Linda L, Hernandez Brenda Y, Albright Cheryl L
Transplant Center, The Queen's Medical Center, Honolulu, HI 96813, USA ; Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
J Transplant. 2012;2012:870659. doi: 10.1155/2012/870659. Epub 2012 Dec 4.
Objective. The incidence/death rate of hepatocellular cancer (HCC) is increasing in America, and it is unclear if access to care contributes to this increase. Design/Patients. 575 HCC cases were reviewed for demographics, education, and tumor size. Main Outcome Measures. Endpoints to determine access to HCC care included whether an eligible patient underwent liver transplantation. Results. Transplant patients versus those not transplanted were younger (55.7 versus 61.8 yrs, P < 0.001), males (89.3% versus 74.4%, P = 0.013), and having completed high school (10.1% versus 1.2%, P = 0.016). There were differences in transplant by ethnicity, insurance, and occupation. Transplant patients with HCC had higher median income via census classification ($54,383 versus $49,383, P = 0.046) and self-reported income ($48,948 versus $38,800, P = 0.002). Differences in access may be related to exclusion criteria for liver transplant, as Pacific Islanders were more likely to have tumor size larger than 5 cm compared to Whites and have BMI > 35 (20.7%) compared to Whites (6.4%) and Asians (4.7%). Conclusions. Ethnic differences in access to transplant are associated with socioeconomic status and factors that can disqualify patients (advanced disease/morbid obesity). Efforts to overcome educational barriers and screening for HCC could improve access to transplant.
目的。美国肝细胞癌(HCC)的发病率/死亡率正在上升,目前尚不清楚获得医疗服务是否导致了这一增长。设计/患者。对575例HCC病例的人口统计学、教育程度和肿瘤大小进行了回顾。主要观察指标。确定获得HCC治疗的终点包括符合条件的患者是否接受了肝移植。结果。接受移植的患者与未接受移植的患者相比,年龄更小(55.7岁对61.8岁,P<0.001),男性比例更高(89.3%对74.4%,P = 0.013),且完成高中学业的比例更高(10.1%对1.2%,P = 0.016)。在种族、保险和职业方面,移植情况存在差异。患有HCC的移植患者通过人口普查分类的中位数收入更高(54,383美元对49,383美元,P = 0.046),自我报告的收入也更高(48,948美元对38,800美元,P = 0.002)。获得医疗服务的差异可能与肝移植的排除标准有关,因为与白人相比,太平洋岛民的肿瘤大小更有可能大于5厘米,且身体质量指数(BMI)>35的比例更高(20.7%),而白人这一比例为6.4%,亚洲人为4.7%。结论。获得移植的种族差异与社会经济地位以及可能使患者失去资格的因素(晚期疾病/病态肥胖)有关。克服教育障碍和进行HCC筛查的努力可能会改善移植的可及性。