Kooper Angelique J A, Pieters Jacqueline J P M, Eggink Alex J, Feuth Ton B, Feenstra Ilse, Wijnberger Lia D E, Rijnders Robbert J P, Quartero Rik W P, Boekkooi Peter F, van Vugt John M G, Smits Arie P T
Department of Human Genetics, Nijmegen Medical Centre, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands.
ISRN Obstet Gynecol. 2012;2012:524537. doi: 10.5402/2012/524537. Epub 2012 Dec 12.
Objectives. The aim of this study was to determine whether prospective parents, primarily referred for prenatal diagnosis to exclude Down syndrome, prefer to know the fetal sex as part of invasive testing. Methods. In this prospective study 400 pregnant women undergoing amniocentesis were invited to answer a questionnaire, including information about demographic factors, current pregnancy, and previous children. In two open-ended questions they were asked why they wanted to know the fetal sex after amniocentesis or ultrasound investigation. Scores were given for reasons that could have played a role in the wish whether or not to know the sex of their unborn child. Results. A total of 210 (52.5%) questionnaires were completed. Overall, 69.0% was interested to know the fetal sex as part of the diagnostic test result. The most important reasons were curiosity (77.8%), "just want to know" (68.0%), and "because it is possible" (66.8%). The overall knowledge of sex chromosomal disorders appeared low and did not seem to affect the parent's wish to know the fetal sex. Almost all women (96.6%) planned to have a 20-week ultrasound scan and 96.2% thought the scan to be reliable in detecting the fetal sex. A minority (28%) was willing to learn the fetal sex by ultrasound examination, whereas 65% preferred to learn the fetal sex only after the amniocentesis. Conclusion. Personal values affect the parental desire to know or not to know the fetal sex. This does not appear to be affected by invasive prenatal testing and/or genetic knowledge of sex chromosomal disorders.
目的。本研究的目的是确定主要因进行产前诊断以排除唐氏综合征而前来咨询的准父母是否希望在侵入性检测中了解胎儿性别。方法。在这项前瞻性研究中，邀请了400名接受羊膜穿刺术的孕妇回答一份问卷，问卷包括人口统计学因素、当前妊娠情况以及既往子女情况。在两个开放式问题中，询问她们在羊膜穿刺术或超声检查后为何想了解胎儿性别。对可能影响其是否希望了解未出生孩子性别的原因进行评分。结果。共完成210份（52.5%）问卷。总体而言，69.0%的人有兴趣在诊断检测结果中了解胎儿性别。最重要的原因是好奇（77.8%）、“就是想知道”（68.0%）以及“因为有可能知道”（66.8%）。对性染色体疾病的总体了解似乎较低，且似乎并未影响父母了解胎儿性别的意愿。几乎所有女性（96.6%）计划进行20周超声扫描，96.2%的人认为该扫描在检测胎儿性别方面可靠。少数人（28%）愿意通过超声检查了解胎儿性别，而65%的人更愿意仅在羊膜穿刺术后了解胎儿性别。结论。个人价值观会影响父母了解或不了解胎儿性别的意愿。这似乎不受侵入性产前检测和/或性染色体疾病的遗传知识的影响。
