Liolios Antonios, Sentissi Othman
Department of Mental Health and Psychiatry, University Hospitals of Geneva, 35 Rue des Bains, 1205 Geneva, Switzerland.
Case Rep Psychiatry. 2012;2012:347421. doi: 10.1155/2012/347421. Epub 2012 Dec 13.
Background. During the past few years, there have been a number of case reports concerning rhabdomyolysis following quetiapine poisoning; however, there has been none concerning the medication in its extended-release form. Methods. We present the case report of a 48-year-old man presenting a major depressive disorder and borderline personality disorder, who after voluntary intoxication with 12000 mg of quetiapine extended-release developed signs of acute rhabdomyolysis. Results. The rhabdomyolysis was confirmed by the laboratory and the clinical findings, with elevated levels of creatinine, creatine phosphokinase, and CRP. Discussion. We would like to pinpoint the importance of this complication and our concern of prescribing it for psychiatric patients with chronic somatic comorbidities.
背景。在过去几年中，有一些关于喹硫平中毒后横纹肌溶解的病例报告；然而，尚无关于其缓释剂型药物的此类报告。方法。我们报告一例48岁男性病例，该患者患有重度抑郁症和边缘性人格障碍，在自愿服用12000毫克喹硫平缓释剂后出现急性横纹肌溶解的症状。结果。实验室检查和临床发现证实了横纹肌溶解，肌酐、肌酸磷酸激酶和CRP水平升高。讨论。我们想强调这种并发症的重要性，以及我们对为患有慢性躯体合并症的精神病患者开具此药的担忧。
