Tahmasebpour A, Rafiee N Baradaran, Ghaffari S, Jamal A
Iranian Fetal Medicine Foundation, Tehran, Iran.
Iran J Public Health. 2012;41(11):92-7. Epub 2012 Nov 1.
To study the outcome of cases with nuchal translucency (NT) ≥ 95th centile in the first trimester of pregnancy.
This cross sectional study was performed at Iranian Fetal Medicine Foundation (FMF) between January 2009 and December 2011. Totally, 186 cases with NT≥ 95th centile who attended for the first trimester screening were studied. All cases with increased NT including those with normal karyotype were followed up with anomaly scan at 18-22 weeks and fetal echocardiography at 22-24 weeks. Pregnancy outcome was extracted from delivery records and pediatrics notes and telephone interviews.
Of screened cases, 186 fetuses had an NT≥95th centile, of them 19.8% were abnormal karyotype, including 29 cases of trisomy 21, three of trisomy 18, two of trisomy 13, three of Turner syndrome. 77.8% did not show any abnormalities on follow-up examinations. 4.6% of cases were found to have malformation antenatally and 4% cases postnatally. 11.4% women elected termination of pregnancy without further follow up. There were 4.6% fetal loss and 1.3% hydrops fetalis.
In this unselected population, the study showed one out of four fetuses with enlarged NT had an adverse pregnancy outcome (miscarriage, fetal loss, and fetal abnormalities), however the chance of having a normal child after exclusion of chromosomal abnormalities and adverse pregnancy outcome was 95%.
研究妊娠早期颈项透明层（NT）≥第95百分位数病例的结局。
这项横断面研究于2009年1月至2011年12月在伊朗胎儿医学基金会（FMF）进行。总共研究了186例参加早期筛查且NT≥第95百分位数的病例。所有NT值升高的病例，包括那些核型正常的病例，均在孕18 - 22周进行了畸形扫描，并在孕22 - 24周进行了胎儿超声心动图检查。从分娩记录、儿科病历及电话访谈中提取妊娠结局。
在筛查的病例中，186例胎儿NT≥第95百分位数，其中19.8%核型异常，包括21 -三体综合征29例、18 -三体综合征3例、13 -三体综合征2例、特纳综合征3例。77.8%的病例在随访检查中未显示任何异常。4.6%的病例产前发现有畸形，4%的病例产后发现有畸形。11.4%的女性选择终止妊娠而未进一步随访。有4.6%的胎儿丢失，1.3%的胎儿水肿。
在这个未经过筛选的人群中，研究表明NT增大的胎儿中有四分之一妊娠结局不良（流产、胎儿丢失及胎儿异常），然而在排除染色体异常和不良妊娠结局后，生出正常孩子的几率为95%。
