一种高效的手性有机催化对芳基甲基酮与 2-呋喃酮的对映选择性迈克尔加成反应：高官能化的手性 3,4-取代的内酯。
An efficient organocatalytic enantioselective Michael addition of aryl methyl ketones with 2-furanones: highly functionalized chiral 3,4-substituted lactones.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
出版信息
Chem Commun (Camb). 2013 Feb 14;49(13):1333-5. doi: 10.1039/c2cc35488h. Epub 2013 Jan 10.
PMID:23304701
Abstract
The efficient asymmetric Michael addition reactions of aryl methyl ketones with 2-furanones were catalyzed by a simple and commercially available chiral 1,2-diphenyl-1,2-ethanediamine and p-TSA·H(2)O as cocatalyst with good yields (up to 95%) and excellent enantioselectivities (up to >99% ee). A bi-functional catalytic mechanism for the reaction was proposed.
摘要
简单易得的手性 1,2-二苯基-1,2-乙二胺与对甲苯磺酸一水合物（p-TSA·H(2)O）共同作为共催化剂，可高效催化芳基甲基酮与呋喃-2-酮的不对称迈克尔加成反应，获得了优异的产率（高达 95%）和对映选择性（高达 >99%ee）。提出了该反应的双功能催化机理。
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