新型二亚胺催化机制下的环戊酮与查耳酮的高对映选择性迈克尔加成反应。
Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, 100191, Beijing, PR China.
出版信息
Chem Commun (Camb). 2010 Mar 14;46(10):1751-3. doi: 10.1039/b915852a. Epub 2010 Jan 12.
DOI:10.1039/b915852a
PMID:20177638
Abstract
The highly efficient asymmetric Michael addition reactions of cyclopentanone with chalcones were catalyzed by a simple and commercially available chiral 1,2-diaminocyclohexane-hexanedioic acid, and exhibited good yields (up to 92%) and excellent enantioselectivities (up to 99% ee). A new di-iminium mechanism for the reaction was proposed.
摘要
手性 1,2-二氨基环己烷-己二酸催化的环戊酮与查耳酮的高效不对称迈克尔加成反应，具有良好的收率（高达 92%）和优异的对映选择性（高达 99%ee）。提出了一种新的反应双亚氨基机理。
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