Faculty of Pharmacy, Medical College of Qingdao University, Qingdao, P.R. China.
Artif Cells Nanomed Biotechnol. 2013 Aug;41(4):227-31. doi: 10.3109/21691401.2012.749482. Epub 2013 Jan 10.
The oxaliplatin nanoparticles were prepared with polylactic acid matrix, orthogonal test was applied to optimize the prescriptions, and the qualities of oxaliplatin nanoparticles were characterized by the shape, particle size, encapsulation efficiency (EE), and drug loading (DL). Oxaliplatin nanoparticle was prepared by solution replacement method. The formation of 0.25% Tween80, DMF-water 1:8 (v/v), oxaliplatin-polylactic acid 1:5 (w/w), and 20 mg/ml polylactic acid showed the suitable EE (17.4 ± 0.47%), DL (3.52 ± 0.07%). We observed the shape of oxaliplatin nanoparticles through SEM. The average size of the particles was 120.5 ± 8.7 nm, which was detected by N5 submicron particle size analyzer.
奥沙利铂纳米粒以聚乳酸为基质制备，采用正交试验优化处方，通过形态、粒径、包封率（EE）和载药量（DL）对奥沙利铂纳米粒的质量进行评价。奥沙利铂纳米粒采用溶液置换法制备，以 0.25%吐温 80、DMF-水 1:8（v/v）、奥沙利铂-聚乳酸 1:5（w/w）、20mg/ml 聚乳酸的组成为宜，EE（17.4±0.47%）、DL（3.52±0.07%）较好。通过 SEM 观察奥沙利铂纳米粒的形态，通过 N5 亚微米粒径分析仪检测到粒子的平均粒径为 120.5±8.7nm。
