Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing 210094, China.
J Chromatogr A. 2013 Feb 15;1277:84-92. doi: 10.1016/j.chroma.2012.12.045. Epub 2012 Dec 28.
Methoxyethylamine monosubstituted β-cyclodextrin, mono-6(A)-(2-methoxyethyl-1-ammonium)-6(A)-β-cyclodextrin chloride (MEtAMCD), is synthesized and analytically characterized. Bearing a methoxy group in cyclodextrin rim, MEtAMCD exhibits outstanding enantioselectivities toward ampholytic and acidic racemates in capillary electrophoresis. Driven by inclusion complexation, electrostatic interactions and/or hydrogen bonding, the enantioseparation of MEtAMCD is found to be strongly dependent on various separation parameters including buffer pH, cyclodextrin concentration, applied voltage, separation temperature and organic solvent additives. MEtAMCD demonstrates as a versatile cationic chiral selector for the studied 26 acidic and ampholytic enantiomers.
甲氧基乙基胺单取代β-环糊精，单-6(A)-(2-甲氧基乙基-1-铵基)-6(A)-β-环糊精氯化物（MEtAMCD）被合成并进行了分析表征。MEtAMCD 在环糊精边缘带有一个甲氧基，在毛细管电泳中对两性和酸性外消旋体表现出出色的对映选择性。受包合络合、静电相互作用和/或氢键的驱动，MEtAMCD 的对映体分离强烈依赖于各种分离参数，包括缓冲液 pH 值、环糊精浓度、施加电压、分离温度和有机溶剂添加剂。MEtAMCD 是研究的 26 种酸性和两性对映体的通用阳离子手性选择剂。
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