Levi F, La Vecchia C, Te V C
Registre Vaudois des Tumeurs, Institut Universitaire de médecine sociale et préventive, Lausanne, Switzerland.
Tumori. 1990 Apr 30;76(2):167-71. doi: 10.1177/030089169007600203.
Incidence registration and survival data from various anatomical subsites of gastric cancer have been abstracted from the population-based Cancer Registry of the Swiss Canton of Vaud for the period 1976-87. Overall age-standardized (Vaud population in 1980) incidence rates for all gastric adenocarcinomas were 22.2/100,000 males and 8.3/100,000 females, with a sex ratio of 2.7. The male preponderance was appreciably greater for cardia (5.9 vs 0.9, sex ratio = 6.5) than for distal stomach (10.2 vs 5.0, sex ratio = 2.0). Adenocarcinomas of unspecified origin had an intermediate sex ratio (2.6). The sex ratio for all gastric adenocarcinomas was lower in the third and fourth decades of age (1.3) than at older ages. In relation to calendar period of diagnosis, no appreciable trend with time was observed for adenocarcinomas of the cardia, and only some modest decline was observed for distal stomach, in the presence of stable sex ratios. A marked fall was observed for "other and unspecified" subsites. Thus, the overall decline in the incidence of gastric adenocarcinomas over the calendar period considered was about 20% for males and 30% for females. Five-year survival was significantly higher for cancers arising in the distal stomach (30%) than for cardiac carcinomas (11%), and intermediate for "other and unspecified sites" (19%). These results indicate that adenocarcinomas arising from the cardia and those arising from the distal stomach are considerably heterogeneous in relation to descriptive epidemiology and prognosis. This may have relevant etiological correlates, particularly since carcinoma of the cardia appears to share important epidemiologic features with esophageal cancer.
1976 - 1987年期间，瑞士沃州基于人群的癌症登记处提取了胃癌各个解剖亚部位的发病率登记和生存数据。所有胃腺癌的总体年龄标准化发病率（以1980年沃州人口为标准）为男性22.2/10万，女性8.3/10万，性别比为2.7。贲门部男性优势明显大于胃远端（5.9比0.9，性别比 = 6.5），而胃远端为（10.2比5.0，性别比 = 2.0）。起源不明的腺癌性别比为中间值（2.6）。所有胃腺癌的性别比在30至40岁时较低（1.3），高于其他年龄段。关于诊断的日历时期，贲门腺癌未观察到明显的时间趋势，胃远端仅观察到一些适度下降，性别比保持稳定。“其他和不明”亚部位观察到明显下降。因此，在所考虑的日历时期内，胃腺癌发病率总体下降男性约为20%，女性约为30%。胃远端癌症的五年生存率（30%）显著高于贲门癌（11%），“其他和不明部位”为中间值（19%）。这些结果表明，贲门腺癌和胃远端腺癌在描述性流行病学和预后方面存在相当大的异质性。这可能有相关的病因学关联，特别是因为贲门癌似乎与食管癌有重要的流行病学特征相同。
