Yang P C, Davis S
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195.
Int J Epidemiol. 1988 Jun;17(2):293-7. doi: 10.1093/ije/17.2.293.
Data from the Surveillance, Epidemiology, and End Results (SEER) programme of the National Cancer Institute were utilized to estimate the incidence of adenocarcinoma of the gastric cardia and distal stomach in the US in order to determine whether the epidemiological features of these diseases differ. Based upon 12,562 histologically confirmed cases identified, the annual incidence of gastric cardia adenocarcinoma was 1.1 per 100,000 people and for the distal stomach 3.8 per 100,000. The male-to-female ratio for adenocarcinoma arising in the cardia was 7.0, versus 2.2 for that arising in the distal stomach. The sex ratio shifted across age groups for the gastric cardia and was highest for the 50-59 year age group, but remained relatively stable across age groups for cancers of the distal stomach. Over the decade studied, the sex ratio decreased from 8.0 to 4.6 for gastric cardia tumours, but remained constant for adenocarcinoma of the distal stomach. Blacks were 2.5 times more likely to develop adenocarcinoma of the distal stomach than whites, but had a 50% lower risk of gastric cardia tumours than whites. These results support an emerging concept that adenocarcinoma of the gastric cardia, gastro-oesophageal junction and distal oesophagus may comprise a group of disease which is aetiologically distinct from distal gastric tumours.
美国国立癌症研究所的监测、流行病学和最终结果（SEER）项目的数据被用于估算美国贲门腺癌和远端胃癌的发病率，以确定这些疾病的流行病学特征是否存在差异。基于12562例经组织学确诊的病例，贲门腺癌的年发病率为每10万人中有1.1例，远端胃癌为每10万人中有3.8例。贲门腺癌的男女比例为7.0，而远端胃癌为2.2。贲门癌的性别比例在各年龄组中有所变化，在50-59岁年龄组中最高，但远端胃癌在各年龄组中相对稳定。在研究的十年中，贲门癌肿瘤的性别比例从8.0降至4.6，但远端胃癌腺癌的性别比例保持不变。黑人患远端胃癌的可能性是白人的2.5倍，但患贲门癌肿瘤的风险比白人低50%。这些结果支持了一个新出现的概念，即贲门腺癌、胃食管交界癌和远端食管癌可能构成一组病因与远端胃癌不同的疾病。
