Swięchowicz Sławomir, Ostałowska Alina, Kasperczyk Aleksandra, Nowak Dariusz, Birkner Ewa, Kasperczyk Sławomir
Department of Orthopaedics, Municipal Hospital in Ruda Śląska, Ruda Śląska, Poland.
Pol Orthop Traumatol. 2012 Oct 22;77:105-9.
Osteoarthritis is one of the most common locomotor conditions and the knee is the second most frequently affected articulation. One of therapeutic methods is viscosupplementation involving intra-articular injections of hyaluronic acid preparations. The aim of the study was to evaluate the clinical status and analyse selected biochemical blood parameters in patients with knee osteoarthritis after intra-articular injections of a hyaluronic acid preparation.
MATERIAL/METHODS: Blood was taken from 113 patients, 60 patients with primary and 53 patients with secondary osteoarthritis, who were administered intra-articular injections of a hyaluronic acid preparation into the affected knee, according to the schedule established in the study protocol. Concentration of lipid hydroperoxides in blood plasma was determined, along with that of malondialdehyde in erythrocytes. Plasma concentrations of ceruloplasmin, TAC, albumin, total bilirubin, and uric acid were also determined. Clinical assessment was performed using a modified HHS scale and the WOMAC questionnaire.
Intra-articular administration of a hyaluronic acid preparation significantly reduced pain in the knee and improved its functioning, regardless of the form of osteoarthritis. Not only clinical improvement was observed, but also beneficial changes in the blood antioxidant system.
Comparable clinical improvement was observed in both forms of osteoarthritis of the knee. It was also beneficial changes in blood antioxidant system, especially in the group with secondary osteoarthritis.
骨关节炎是最常见的运动系统疾病之一，膝关节是第二常见受累关节。治疗方法之一是关节腔内注射透明质酸制剂进行粘弹性补充疗法。本研究的目的是评估关节腔内注射透明质酸制剂后膝骨关节炎患者的临床状况，并分析选定的血液生化参数。
材料/方法：根据研究方案确定的时间表，从113例患者中采集血液，其中60例原发性骨关节炎患者和53例继发性骨关节炎患者，均在患侧膝关节进行关节腔内注射透明质酸制剂。测定血浆中脂质过氧化物的浓度以及红细胞中丙二醛的浓度。还测定了血浆中铜蓝蛋白、总抗氧化能力（TAC）、白蛋白、总胆红素和尿酸的浓度。使用改良的HHS量表和WOMAC问卷进行临床评估。
无论骨关节炎的类型如何，关节腔内注射透明质酸制剂均能显著减轻膝关节疼痛并改善其功能。不仅观察到临床改善，而且血液抗氧化系统也发生了有益变化。
两种类型的膝骨关节炎均观察到类似的临床改善。血液抗氧化系统也发生了有益变化，尤其是继发性骨关节炎组。
