Wohlauer Max V, McManus Martine, Fukami Norio, Gajdos Csaba
Section of GI, Tumor and Endocrine Surgery, Department of Surgery, University of Colorado at Denver, Aurora, CO 80045, USA.
JOP. 2013 Jan 10;14(1):77-80. doi: 10.6092/1590-8577/1259.
Cystic tumors of the pancreas have been diagnosed with increasing frequency. Intraductal oncocytic papillary neoplasm is a rare type of cystic pancreatic tumor. Intraductal oncocytic papillary neoplasm is considered a distinct entity with the potential of developing into invasive carcinoma and it should be differentiated from other cystic tumors of the pancreas, including mucinous cystic neoplasm and other forms of intraductal papillary mucinous neoplasm (IPMN). Histologically, the formation of oncocytic cells and the complex morphology of the papillae distinguish intraductal oncocytic papillary neoplasm from IPMN. While the number of publications addressing the diagnosis, management and follow-up of patients with IPMN has been increasing, the behavior differences between IPMN and intraductal oncocytic papillary neoplasm have not been elucidated, secondary to very limited clinical experience.
Here, we are presenting a case of a patient with the diagnosis of intraductal oncocytic papillary neoplasm of the pancreas developing into invasive cancer.
This case stresses the necessity for lifelong surveillance of the remnant pancreas following partial pancreatectomy for intraductal oncocytic papillary neoplasm, due to the risk of developing multifocal disease.
胰腺囊性肿瘤的诊断频率日益增加。导管内嗜酸性乳头状肿瘤是一种罕见的胰腺囊性肿瘤类型。导管内嗜酸性乳头状肿瘤被认为是一种独特的实体，有发展为浸润性癌的可能，应与其他胰腺囊性肿瘤相鉴别，包括黏液性囊性肿瘤和其他形式的导管内乳头状黏液性肿瘤（IPMN）。在组织学上，嗜酸性细胞的形成以及乳头的复杂形态将导管内嗜酸性乳头状肿瘤与IPMN区分开来。虽然关于IPMN患者的诊断、管理和随访的出版物数量不断增加，但由于临床经验非常有限，IPMN与导管内嗜酸性乳头状肿瘤之间的行为差异尚未阐明。
在此，我们报告一例胰腺导管内嗜酸性乳头状肿瘤发展为浸润性癌的患者。
该病例强调，由于存在发生多灶性疾病的风险，对于因导管内嗜酸性乳头状肿瘤行部分胰腺切除术后的残余胰腺，有必要进行终身监测。
