Department of Bioengineering, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA.
Appl Biochem Biotechnol. 2013 Feb;169(4):1134-46. doi: 10.1007/s12010-012-9999-7. Epub 2013 Jan 10.
We have prepared and characterized a new polyurethane-based antimicrobial material, N,N-dodecyl,methyl-polyurethane (Quat-12-PU). It exhibits strong antiviral and antibacterial activities when coated (as an organic solution or an aqueous nanosuspension) onto surfaces and antibacterial activity when electrospun into nanofibers. Quat-12-PU surfaces are able to kill airborne Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria, as well as inactivate the enveloped influenza virus (but not the non-enveloped poliovirus).
我们制备并表征了一种新型基于聚氨酯的抗菌材料，N,N-十二烷基，甲基-聚氨酯（季铵盐-12-PU）。当涂覆在表面上（作为有机溶液或水性纳米混悬液）时，它表现出很强的抗病毒和抗菌活性，而当静电纺成纳米纤维时，它具有抗菌活性。季铵盐-12-PU 表面能够杀死空气中的革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌细菌，并使包膜流感病毒失活（但不能使非包膜脊髓灰质炎病毒失活）。
