School of Chemical Engineering, Department of Materials and Bioprocess Engineering, University of Campinas, Campinas, São Paulo 13083-852, Brazil.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Colloids Surf B Biointerfaces. 2022 Sep;217:112693. doi: 10.1016/j.colsurfb.2022.112693. Epub 2022 Jul 8.
Coronavirus pandemic has evidenced the importance of creating bioactive materials to mitigate viral infections, especially in healthcare settings and public places. Advances in antiviral coatings have led to materials with impressive antiviral performance; however, their application may face health and environmental challenges. Bio-inspired antimicrobial peptides (AMPs) are suitable building blocks for antimicrobial coatings due to their versatile design, scalability, and environmentally friendly features. This review presents the advances and opportunities on the AMPs to create virucidal coatings. The review first describes the fundamental characteristics of peptide structure and synthesis, highlighting the recent findings on AMPs and the role of peptide structure (α-helix, β-sheet, random, and cyclic peptides) on the virucidal mechanism. The following section presents the advances in AMPs coating on medical devices with a detailed description of the materials coated and the targeted pathogens. The use of peptides in vaccine formulations is also reported, emphasizing the molecular interaction of peptides with different viruses and the current clinical stage of each formulation. The role of several materials (metallic particles, inorganic materials, and synthetic polymers) in the design of antiviral coatings is also presented, discussing the advantages and the drawbacks of each material. The final section offers future directions and opportunities for using AMPs on antiviral coatings to prevent viral outbreaks.
冠状病毒大流行证明了创造具有生物活性的材料来减轻病毒感染的重要性，特别是在医疗保健环境和公共场所。抗病毒涂料的进步导致了具有令人印象深刻的抗病毒性能的材料；然而，它们的应用可能会面临健康和环境方面的挑战。抗菌肽（AMPs）是抗菌涂料的合适构建块，因为它们具有多功能设计、可扩展性和环保特性。这篇综述介绍了 AMPs 用于制造杀病毒涂层的进展和机会。综述首先描述了肽结构和合成的基本特征，强调了最近关于 AMPs 的发现以及肽结构（α-螺旋、β-折叠、无规和环状肽）在杀病毒机制中的作用。接下来的部分介绍了 AMPs 在医疗器械上的涂层进展，详细描述了涂层的材料和靶向病原体。还报告了肽在疫苗配方中的应用，强调了肽与不同病毒的分子相互作用以及每种配方的当前临床阶段。还讨论了几种材料（金属颗粒、无机材料和合成聚合物）在抗病毒涂料设计中的作用，讨论了每种材料的优点和缺点。最后一部分提供了使用 AMPs 进行抗病毒涂层以预防病毒爆发的未来方向和机会。
