Tokarenko I I
Vrach Delo. 1990 Jan(1):64-7.
A study of 38 patients with hypertensive disease revealed that anaprilin is an effective hypotensive agent. Administration of anaprilin (120-160 mg daily) produced a redistribution of the peripheral blood supply in the abdominal cavity, crus, finger and head. In regions with normal blood supply level it decreased while in regions with a reduced supply it increased. This redistribution is an important compensatory mechanism of limitation of ischemia in the regions but is worsening the blood supply in all regions in most patients. Pathogenetic treatment of patients with hypertensive disease (grade II) requires individual control of its effect on the central and peripheral hemodynamics and their early correction by adding vasodilating and diuretic agents as well as those improving blood supply of the brain.
一项对38例高血压病患者的研究表明，心得安是一种有效的降压药。服用心得安（每日120 - 160毫克）会使腹腔、小腿、手指和头部的外周血液供应重新分布。在血液供应水平正常的区域，其血液供应减少，而在供应减少的区域则增加。这种重新分布是限制这些区域缺血的重要代偿机制，但在大多数患者中会使所有区域的血液供应恶化。对II级高血压病患者进行病因治疗需要个别控制其对中心和外周血流动力学的影响，并通过添加血管扩张剂、利尿剂以及改善脑供血的药物对其进行早期纠正。
