Veber V R, Khramov Iu A, Osmolovskiĭ V S, Solov'eva T A
Klin Med (Mosk). 1989 Mar;67(3):46-8.
The hemodynamic effects of anaprilin at various hours of the day in patients with essential hypertension depends on the initial type of central hemodynamics. The negative inotropic effect of anaprilin in the hyperkinetic type is revealed with high frequency at all hours of the day, in the eukinetic type at 10 p. m. and in the hypokinetic type at 5 p. m. In the initial hyperkinetic type of hemodynamics the hypotensive effect of anaprilin is pronounced at midday and 10 p.m., in the eukinetic type at 7 a. m., midday and 5 p. m. and in the hypokinetic type at 7 a. m.