Veber V R, Khramov Iu A, Osmolovskiĭ V S, Solov'eva T A
Klin Med (Mosk). 1989 Mar;67(3):46-8.
The hemodynamic effects of anaprilin at various hours of the day in patients with essential hypertension depends on the initial type of central hemodynamics. The negative inotropic effect of anaprilin in the hyperkinetic type is revealed with high frequency at all hours of the day, in the eukinetic type at 10 p. m. and in the hypokinetic type at 5 p. m. In the initial hyperkinetic type of hemodynamics the hypotensive effect of anaprilin is pronounced at midday and 10 p.m., in the eukinetic type at 7 a. m., midday and 5 p. m. and in the hypokinetic type at 7 a. m.
心得安对原发性高血压患者一天中不同时段的血液动力学效应取决于中心血液动力学的初始类型。心得安对高动力型的负性肌力作用在一天中的所有时段都高频出现，对正常动力型在晚上10点出现，对低动力型在下午5点出现。在初始高动力型血液动力学状态下，心得安的降压作用在中午和晚上10点明显，在正常动力型在早上7点、中午和下午5点明显，在低动力型在早上7点明显。
