Laboratorio de Neurofisiología Integrativa, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan, México, D.F., C.P. 14370, Mexico.
Inflammation. 2013 Jun;36(3):658-64. doi: 10.1007/s10753-012-9589-4.
The temporal activation of the sensory systems, especially in pain, determines intermediate states that define the future of the response to sensory stimulation. In this work, we interfere pharmacologically with those states that produce peripheral and central sensitisation after an acute inflammatory process, inhibiting at the periphery the COX-2 with celecoxib and using taurine (glycine A receptor agonist) for central pain relief. We tested the paw withdrawal reflex latencies to thermo- and mechanonociception after the induction of an acute inflammatory process with carrageenan. Celecoxib at low doses [0.13 and 1.3 mg/kg, intraperitoneal (i.p.)] in combination with taurine (300 mg/kg, i.p.) produces a decrease of the nociceptive response in thermo- and mechanonociception, as compared with the effect of both drugs alone. We propose that the enhancement of the analgesic effect of celecoxib in combination with taurine could be due the simultaneous action of these drugs at both, peripheral and central levels.
感觉系统的时间激活，特别是在疼痛中，决定了中间状态，这些状态定义了对感觉刺激反应的未来。在这项工作中，我们通过药理学手段干扰急性炎症过程后产生的外周和中枢敏化的状态，通过使用塞来昔布抑制外周的 COX-2，并使用牛磺酸（甘氨酸 A 受体激动剂）来缓解中枢疼痛。我们在角叉菜胶诱导急性炎症过程后，通过测试热和机械伤害感受的足底撤回反射潜伏期来检测这一现象。与单独使用两种药物相比，低剂量的塞来昔布（0.13 和 1.3mg/kg，腹腔内注射）与牛磺酸（300mg/kg，腹腔内注射）联合使用，可降低热和机械伤害感受的痛觉反应。我们提出，塞来昔布与牛磺酸联合使用增强其镇痛效果可能是由于这两种药物同时在外周和中枢水平发挥作用。
