J Natl Compr Canc Netw. 2013 Jan 1;11(1):78-98. doi: 10.6004/jnccn.2013.0011.
Neuroendocrine tumors account for approximately 20% of lung cancers; most (≈15%) are small cell lung cancer (SCLC). These NCCN Clinical Practice Guidelines in Oncology for SCLC focus on extensive-stage SCLC because it occurs more frequently than limited-stage disease. SCLC is highly sensitive to initial therapy; however, most patients eventually die of recurrent disease. In patients with extensive-stage disease, chemotherapy alone can palliate symptoms and prolong survival in most patients; however, long-term survival is rare. Most cases of SCLC are attributable to cigarette smoking; therefore, smoking cessation should be strongly promoted.
神经内分泌肿瘤约占肺癌的 20%；其中大多数（≈15%）为小细胞肺癌（SCLC）。这些 NCCN 肿瘤学临床实践指南专注于广泛期 SCLC，因为它比局限期疾病更为常见。SCLC 对初始治疗高度敏感；然而，大多数患者最终死于复发性疾病。在广泛期疾病患者中，单独化疗可以缓解症状并延长大多数患者的生存时间；然而，长期生存较为罕见。大多数 SCLC 归因于吸烟；因此，应强烈提倡戒烟。
