Vreman H J, Stevenson D K
Department of Pediatrics, Stanford University School of Medicine, CA 94305.
Am J Dis Child. 1990 May;144(5):590-4. doi: 10.1001/archpedi.1990.02150290084034.
Solutions of bilirubin containing human serum albumin were exposed in vitro in the presence of 10 mumols/L of tin and zinc metalloporphyrins at 37 degrees C for 30 minutes to light sources used clinically for phototherapy of neonates. Bilirubin in the model solutions was photodegraded to approximately 60% of dark control in cool white light (17 microW/cm2 per nanometer). The presence of zinc protoporphyrin and zinc mesoporphyrin further reduced the bilirubin concentration slightly, but the tin analogues caused a significant enhancement of degradation to 35% and 25% of dark control, respectively. The results provide evidence that the zinc and tin metalloporphyrins are photosensitizers capable of enhancing the native photodegradation of bilirubin in biologic matrices, but that the tin compounds are more potent. The metalloporphyrin time course, dose-response curve, oxygen effects, and efficacy of phototherapy light sources were also studied.
含有人类血清白蛋白的胆红素溶液在体外，于37摄氏度、10微摩尔/升的锡和锌金属卟啉存在的情况下，暴露于临床上用于新生儿光疗的光源下30分钟。模型溶液中的胆红素在冷白色光（每纳米17微瓦/平方厘米）下光降解至黑暗对照的约60%。锌原卟啉和锌中卟啉的存在进一步略微降低了胆红素浓度，但锡类似物分别导致降解显著增强至黑暗对照的35%和25%。结果证明，锌和锡金属卟啉是能够增强生物基质中胆红素天然光降解的光敏剂，但锡化合物的作用更强。还研究了金属卟啉的时间进程、剂量反应曲线、氧效应以及光疗光源的疗效。
