补充抗坏血酸对年轻成年女性血液学反应及抗坏血酸状态的影响。

Effect of ascorbic acid supplementation on haematological response and ascorbic acid status of young female adults.

作者信息

Ajayi O A, Nnaji U R

机构信息

Department of Human Nutrition, College of Medicine, University of Ibadan, Nigeria.

出版信息

Ann Nutr Metab. 1990;34(1):32-6. doi: 10.1159/000177567.

DOI:10.1159/000177567

PMID:2331138

Abstract

Haematological response and ascorbic acid (AA) status were evaluated in 32 young adult females (age 20-34 years) 8 weeks after supplementation with two levels of AA (50 and 100 mg). Both levels of AA intake produced a similar response marked by significant elevation (p less than 0.01) in Hb concentration, Hct level, RBC count, serum and leucocyte ascorbate concentrations. Ten weeks after withdrawal of the supplements, values for all parameters evaluated decreased significantly (p less than 0.01) to presupplementation levels. Haemoglobin concentration and leucocyte ascorbate remained relatively higher (p less than 0.01) than initial values in subjects who received 100 mg AA. This study showed that AA supplementation improved erythropoietic activity and AA status of our female population. However, the higher dose of AA (100 mg) sustained Hb concentration and tissue ascorbate longer after withdrawal of supplementation.

摘要

在32名年轻成年女性（年龄20 - 34岁）补充两种剂量（50毫克和100毫克）的抗坏血酸（AA）8周后，评估血液学反应和AA状态。两种AA摄入量均产生了相似的反应，表现为血红蛋白浓度、血细胞比容水平、红细胞计数、血清和白细胞抗坏血酸浓度显著升高（p小于0.01）。补充剂停用10周后，所有评估参数的值均显著下降（p小于0.01）至补充前水平。在接受100毫克AA的受试者中，血红蛋白浓度和白细胞抗坏血酸水平仍相对高于初始值（p小于0.01）。本研究表明，补充AA可改善我们女性群体的红细胞生成活性和AA状态。然而，较高剂量的AA（100毫克）在补充剂停用后能使血红蛋白浓度和组织抗坏血酸维持更长时间。