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Dramatic increase of third-generation cephalosporin-resistant E. coli in German intensive care units: secular trends in antibiotic drug use and bacterial resistance, 2001 to 2008.第三代头孢菌素耐药大肠杆菌在德国重症监护病房急剧增加:2001 至 2008 年抗生素药物使用和细菌耐药性的长期趋势。
Crit Care. 2010;14(3):R113. doi: 10.1186/cc9062. Epub 2010 Jun 14.
2
Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis.基层医疗中抗生素处方对个体患者抗菌药物耐药性的影响:系统评价和荟萃分析。
BMJ. 2010 May 18;340:c2096. doi: 10.1136/bmj.c2096.
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Health Alliance for Prudent Prescribing, Yield and Use of Antimicrobial Drugs in the Treatment of Respiratory Tract Infections (HAPPY AUDIT).审慎处方、优化抗菌药物使用以治疗呼吸道感染联盟(HAPPY AUDIT)。
BMC Fam Pract. 2010 Apr 23;11:29. doi: 10.1186/1471-2296-11-29.
4
Diagnosis-prescribing surveys in 2000, 2002 and 2005 in Swedish general practice: consultations, diagnosis, diagnostics and treatment choices.2000年、2002年和2005年瑞典全科医疗中的诊断-处方调查:会诊、诊断、诊断方法及治疗选择
Scand J Infect Dis. 2008;40(8):648-54. doi: 10.1080/00365540801932439.
5
Antimicrobial drug use and resistance in Europe.欧洲抗菌药物的使用与耐药性
Emerg Infect Dis. 2008 Nov;14(11):1722-30. doi: 10.3201/eid1411.070467.
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Seasonality of antibiotic-resistant streptococcus pneumoniae that causes acute otitis media: a clue for an antibiotic-restriction policy?导致急性中耳炎的耐抗生素肺炎链球菌的季节性:抗生素限制政策的一个线索?
J Infect Dis. 2008 Apr 15;197(8):1094-102. doi: 10.1086/528995.
7
European Surveillance of Antimicrobial Consumption (ESAC): outpatient antibiotic use in Europe.欧洲抗菌药物消费监测(ESAC):欧洲门诊抗生素使用情况
J Antimicrob Chemother. 2006 Aug;58(2):401-7. doi: 10.1093/jac/dkl188. Epub 2006 May 30.
8
Outpatient antibiotic use in Europe and association with resistance: a cross-national database study.欧洲门诊抗生素使用情况及其与耐药性的关联:一项跨国数据库研究。
Lancet. 2005;365(9459):579-87. doi: 10.1016/S0140-6736(05)17907-0.
9
A European study on the relationship between antimicrobial use and antimicrobial resistance.一项关于抗菌药物使用与抗菌药物耐药性之间关系的欧洲研究。
Emerg Infect Dis. 2002 Mar;8(3):278-82. doi: 10.3201/eid0803.010192.
10
Antibiotic use by indication: a basis for active antibiotic policy in the community.按适应证使用抗生素:社区积极抗生素政策的基础。
Scand J Infect Dis. 2001;33(12):920-6. doi: 10.1080/00365540110077056.

拉脱维亚全科医生抗生素处方评估。

Assessment of antibiotic prescribing in Latvian general practitioners.

机构信息

Department of Infection Control, Pauls Stradins University Hospital, Pilsonu street 12, LV-1002, Riga, Latvia.

出版信息

BMC Fam Pract. 2013 Jan 12;14:9. doi: 10.1186/1471-2296-14-9.

DOI:10.1186/1471-2296-14-9
PMID:23311389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3562523/
Abstract

BACKGROUND

Though general antibiotic consumption data is available, information on the actual patterns of prescribing antibiotics locally is difficult to obtain. An easy to use methodology was designed to assess ambulatory management of infections by Latvian general practitioners (GPs).

METHODS

GPs were asked to record data in a patient data collection form for every patient that received antibiotics. Study period - (7 days) one week in November, 2008. Data recorded included the following details: an antibiotic, the prescribed dose, dosing interval, route of administration combined with the demographic factors of the patient and clinical diagnosis based on a pre-defined list.

RESULTS

Two hundred forty eight forms out of the 600 (41%) were returned by post. Antibiotics were prescribed in 6.4% (1711/26803) of outpatient consultations. In total, 1763 antibiotics were prescribed during the study period. Ninety seven percent of the patients received monotherapy and only 47 (2.7%) patients were prescribed two antibiotics. The most commonly prescribed antibiotics were amoxicillin (33.9% of prescribed), amoxicillin/clavulanate (18,7%) and clarithromycin (7.6%). The most commonly treated indications were pharyngitis (29.8%), acute bronchitis (25.3%) and rhinosinusitis (10.2%). Pneumonia was mostly treated with amoxicillin/clavulanate (25,7%), amoxicillin (15.7%) and clarithromycin (19.3%).

CONCLUSIONS

Methodology employed provided useful additional information on ambulatory practice of prescribing antibiotics and could be used in further assessment studies. Educational interventions should be focused on treatment of acute pharyngitis and bronchitis in children and unnecessary use of quinolones in adults for uncomplicated urinary tract infection.

摘要

背景

虽然有一般抗生素使用数据,但很难获得当地实际处方抗生素模式的信息。我们设计了一种简单易用的方法,用于评估拉脱维亚全科医生(GP)对感染的门诊管理。

方法

要求 GP 为每一位接受抗生素治疗的患者在患者数据采集表中记录数据。研究期间为 2008 年 11 月的一周(7 天)。记录的数据包括以下详细信息:抗生素、规定剂量、给药间隔、给药途径以及患者的人口统计学因素和基于预定义清单的临床诊断。

结果

通过邮寄方式共收回 600 份表格中的 248 份(41%)。在 26803 次门诊咨询中,有 6.4%(1711/26803)开出了抗生素。在研究期间共开出了 1763 种抗生素。97%的患者接受单药治疗,只有 47 名(2.7%)患者同时开了两种抗生素。最常开的抗生素是阿莫西林(33.9%)、阿莫西林/克拉维酸(18.7%)和克拉霉素(7.6%)。最常见的治疗指征是咽炎(29.8%)、急性支气管炎(25.3%)和鼻-鼻窦炎(10.2%)。肺炎主要用阿莫西林/克拉维酸(25.7%)、阿莫西林(15.7%)和克拉霉素(19.3%)治疗。

结论

所采用的方法提供了有关门诊开抗生素处方实践的有用补充信息,可用于进一步评估研究。教育干预应侧重于儿童急性咽炎和支气管炎的治疗以及成人不必要地将喹诺酮类药物用于治疗单纯性尿路感染。