• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

慢性大麻使用者中儿茶酚-O-甲基转移酶Val(158)Met多态性对脑结构的调节作用。

Modulation of brain structure by catechol-O-methyltransferase Val(158) Met polymorphism in chronic cannabis users.

作者信息

Batalla Albert, Soriano-Mas Carles, López-Solà Marina, Torrens Marta, Crippa José A, Bhattacharyya Sagnik, Blanco-Hinojo Laura, Fagundo Ana B, Harrison Ben J, Nogué Santiago, de la Torre Rafael, Farré Magí, Pujol Jesús, Martín-Santos Rocío

机构信息

Department of Psychiatry, Clinical Institute of Neuroscience, Hospital Clínic, IDIBAPS, CIBERSAM, Spain; Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain.

出版信息

Addict Biol. 2014 Jul;19(4):722-32. doi: 10.1111/adb.12027. Epub 2013 Jan 14.

DOI:10.1111/adb.12027
PMID:23311613
Abstract

Neuroimaging studies have shown that chronic consumption of cannabis may result in alterations in brain morphology. Recent work focusing on the relationship between brain structure and the catechol-O-methyltransferase (COMT) gene polymorphism suggests that functional COMT variants may affect brain volume in healthy individuals and in schizophrenia patients. We measured the influence of COMT genotype on the volume of four key regions: the prefrontal cortex, neostriatum (caudate-putamen), anterior cingulate cortex and hippocampus-amygdala complex, in chronic early-onset cannabis users and healthy control subjects. We selected 29 chronic cannabis users who began using cannabis before 16 years of age and matched them to 28 healthy volunteers in terms of age, educational level and IQ. Participants were male, Caucasians aged between 18 and 30 years. All were assessed by a structured psychiatric interview (PRISM) to exclude any lifetime Axis-I disorder according to Diagnostic and Statistical Manual for Mental Disorders-Fourth Edition. COMT genotyping was performed and structural magnetic resonance imaging data was analyzed by voxel-based morphometry. The results showed that the COMT polymorphism influenced the volume of the bilateral ventral caudate nucleus in both groups, but in an opposite direction: more copies of val allele led to lesser volume in chronic cannabis users and more volume in controls. The opposite pattern was found in left amygdala. There were no effects of COMT genotype on volumes of the whole brain or the other selected regions. Our findings support recent reports of neuroanatomical changes associated with cannabis use and, for the first time, reveal that these changes may be influenced by the COMT genotype.

摘要

神经影像学研究表明,长期吸食大麻可能导致大脑形态改变。最近一项关注脑结构与儿茶酚-O-甲基转移酶(COMT)基因多态性之间关系的研究表明,功能性COMT变体可能会影响健康个体和精神分裂症患者的脑容量。我们测量了COMT基因型对四个关键区域体积的影响:前额叶皮质、新纹状体(尾状核-壳核)、前扣带回皮质和海马-杏仁核复合体,研究对象为慢性早发性大麻使用者和健康对照者。我们选取了29名在16岁之前开始吸食大麻的慢性大麻使用者,并将他们与28名健康志愿者在年龄、教育水平和智商方面进行匹配。参与者均为18至30岁的白人男性。所有参与者均通过结构化精神病学访谈(PRISM)进行评估,以排除根据《精神疾病诊断与统计手册(第四版)》诊断的任何终生轴I障碍。进行了COMT基因分型,并通过基于体素的形态学分析对结构磁共振成像数据进行了分析。结果表明,COMT多态性对两组双侧腹侧尾状核的体积均有影响,但方向相反:缬氨酸等位基因拷贝数越多,慢性大麻使用者的脑体积越小,而对照组的脑体积越大。在左侧杏仁核中发现了相反的模式。COMT基因型对全脑或其他选定区域的体积没有影响。我们的研究结果支持了最近关于大麻使用相关神经解剖学变化的报道,并首次揭示这些变化可能受COMT基因型的影响。

相似文献

1
Modulation of brain structure by catechol-O-methyltransferase Val(158) Met polymorphism in chronic cannabis users.慢性大麻使用者中儿茶酚-O-甲基转移酶Val(158)Met多态性对脑结构的调节作用。
Addict Biol. 2014 Jul;19(4):722-32. doi: 10.1111/adb.12027. Epub 2013 Jan 14.
2
Relationship of catechol-O-methyltransferase variants to brain structure and function in a population at high risk of psychosis.儿茶酚-O-甲基转移酶变异体与精神病高风险人群脑结构和功能的关系。
Biol Psychiatry. 2007 May 15;61(10):1127-34. doi: 10.1016/j.biopsych.2006.05.020. Epub 2006 Oct 2.
3
Relationship between the catechol-O-methyl transferase Val108/158Met genotype and brain volume in treatment-naive major depressive disorder: Voxel-based morphometry analysis.未经治疗的首发重性抑郁障碍患者儿茶酚-O-甲基转移酶 Val108/158Met 基因型与脑容量的关系:基于体素的形态计量学分析。
Psychiatry Res. 2015 Sep 30;233(3):481-7. doi: 10.1016/j.pscychresns.2015.07.024. Epub 2015 Jul 31.
4
Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met polymorphism.大麻使用与精神病发病年龄:与 COMT Val158Met 多态性相互作用的进一步证据。
Acta Psychiatr Scand. 2011 Jun;123(6):485-92. doi: 10.1111/j.1600-0447.2010.01665.x. Epub 2011 Jan 14.
5
The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia.儿茶酚-O-甲基转移酶基因Val158Met多态性与慢性精神分裂症患者脑形态异常的关联
Brain. 2006 Feb;129(Pt 2):399-410. doi: 10.1093/brain/awh702. Epub 2005 Dec 5.
6
The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val¹⁵⁸Met polymorphism.童年期虐待和大麻使用对成年期精神病症状的影响受 COMT Val¹⁵⁸Met 多态性的调节。
Schizophr Res. 2013 Oct;150(1):303-11. doi: 10.1016/j.schres.2013.07.020. Epub 2013 Aug 15.
7
Genetic Variation in the Catechol-O-Methyl Transferase Val108/158Met Is Linked to the Caudate and Posterior Cingulate Cortex Volume in Healthy Subjects: Voxel-Based Morphometry Analysis of Brain Magnetic Resonance Imaging.儿茶酚-O-甲基转移酶Val108/158Met基因变异与健康受试者的尾状核及后扣带回皮质体积相关:基于体素的脑磁共振成像形态学分析
PLoS One. 2015 Nov 13;10(11):e0142862. doi: 10.1371/journal.pone.0142862. eCollection 2015.
8
Association between catechol-O-methyltrasferase Val108/158Met genotype and prefrontal hemodynamic response in schizophrenia.儿茶酚-O-甲基转移酶Val108/158Met基因型与精神分裂症前额叶血流动力学反应之间的关联。
PLoS One. 2009;4(5):e5495. doi: 10.1371/journal.pone.0005495. Epub 2009 May 8.
9
Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia.儿茶酚氧位甲基转移酶 Val158Met 多态性与精神分裂症的反扫视眼动。
Schizophr Bull. 2010 Jan;36(1):157-64. doi: 10.1093/schbul/sbn064. Epub 2008 Jun 17.
10
[COMT Val158Met polymorphism and schizophrenia in a series of Spanish patients].[一系列西班牙患者中的儿茶酚-O-甲基转移酶(COMT)Val158Met多态性与精神分裂症]
Med Clin (Barc). 2007 Jan 20;128(2):41-4. doi: 10.1157/13097467.

引用本文的文献

1
Cannabis use disorder contributes to cognitive dysfunction in Veterans with traumatic brain injury.大麻使用障碍会导致创伤性脑损伤退伍军人出现认知功能障碍。
Front Neurol. 2024 Jan 16;15:1261249. doi: 10.3389/fneur.2024.1261249. eCollection 2024.
2
The economic impact of cannabis use disorder and dementia diagnosis in veterans diagnosed with traumatic brain injury.患有创伤性脑损伤的退伍军人中,大麻使用障碍和痴呆症诊断的经济影响。
Front Neurol. 2024 Jan 12;14:1261144. doi: 10.3389/fneur.2023.1261144. eCollection 2023.
3
Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants.
对青少年和成年早期大麻使用的结构和功能神经影像学研究的系统评价:来自 90 项研究和 9441 名参与者的证据。
Neuropsychopharmacology. 2022 Apr;47(5):1000-1028. doi: 10.1038/s41386-021-01226-9. Epub 2021 Nov 27.
4
AddictGene: An integrated knowledge base for differentially expressed genes associated with addictive substance.成瘾基因:与成瘾性物质相关的差异表达基因的综合知识库。
Comput Struct Biotechnol J. 2021 Apr 19;19:2416-2422. doi: 10.1016/j.csbj.2021.04.027. eCollection 2021.
5
Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group.经常使用大麻的个体在性别和依赖相关的神经解剖学差异:来自 ENIGMA 成瘾工作组的研究结果。
Transl Psychiatry. 2021 May 6;11(1):272. doi: 10.1038/s41398-021-01382-y.
6
Cannabis and Depression.大麻与抑郁。
Adv Exp Med Biol. 2021;1264:67-80. doi: 10.1007/978-3-030-57369-0_5.
7
How do substance use disorders compare to other psychiatric conditions on structural brain abnormalities? A cross-disorder meta-analytic comparison using the ENIGMA consortium findings.物质使用障碍与其他精神疾病在结构脑异常方面有何不同?使用 ENIGMA 联盟研究结果的跨疾病荟萃分析比较。
Hum Brain Mapp. 2022 Jan;43(1):399-413. doi: 10.1002/hbm.25114. Epub 2020 Jul 9.
8
Identification of 34 genes conferring genetic and pharmacological risk for the comorbidity of schizophrenia and smoking behaviors.鉴定出 34 个基因,这些基因可导致精神分裂症和吸烟行为共病的遗传和药物风险。
Aging (Albany NY). 2020 Feb 3;12(3):2169-2225. doi: 10.18632/aging.102735.
9
Does regular cannabis use affect neuroanatomy? An updated systematic review and meta-analysis of structural neuroimaging studies.经常使用大麻会影响神经解剖学吗?结构神经影像学研究的更新系统评价和荟萃分析。
Eur Arch Psychiatry Clin Neurosci. 2019 Feb;269(1):59-71. doi: 10.1007/s00406-019-00979-1. Epub 2019 Jan 31.
10
The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis.大麻使用与精神病中COMT基因Val158Met多态性之间的相互作用:一项跨诊断荟萃分析。
PLoS One. 2018 Feb 14;13(2):e0192658. doi: 10.1371/journal.pone.0192658. eCollection 2018.