Department of Endocrinology and Thyroid Research Centre, Institute of Nuclear Medicine & Allied Sciences, Delhi, India.
Clin Endocrinol (Oxf). 2013 Sep;79(3):424-8. doi: 10.1111/cen.12148. Epub 2013 May 11.
There is controversy about the relation of thyroid functions and body mass index. The present study was aimed to assess the relationship between thyroid function and body mass index in Indian school children.
Population survey.
Data were collected from 25 schools in 19 cities across five different geographical zones of India. Children, who consented, were evaluated for anthropometry and blood tests. Children were categorized as overweight and obese based on standard BMI criteria.
Serum samples were analysed for free T3, free T4, TSH and anti-TPO antibodies.
A total of 13,691 children in the age group of 5-18 years formed the study population. The mean age and mean BMI were 11·9 ± 3·0 years and 18·48 ± 3·89 kg/m² respectively. Among these, 2119 (15·5%) children were overweight and 536 (3·9%) were obese. Subclinical hypothyroidism was present in 943 (6·9%) children.FT3 and TSH levels increased and FT4 levels decreased with increasing BMI in euthyroid boys and girls. Prevalence of SCH was significantly higher in obese/overweight children (9·0%, vs 6·5%; P = 0·034) as compared with normal BMI children.
Serum FT3 and TSH were positively while FT4 was negatively associated with BMI in apparently healthy euthyroid children.
甲状腺功能与体重指数之间的关系存在争议。本研究旨在评估印度学龄儿童甲状腺功能与体重指数之间的关系。
人群调查。
数据来自印度五个不同地理区域的 19 个城市的 25 所学校。同意的儿童接受了人体测量和血液检查。根据标准 BMI 标准，将儿童分为超重和肥胖。
分析血清样本中的游离 T3、游离 T4、TSH 和抗 TPO 抗体。
共有 13691 名年龄在 5-18 岁的儿童组成了研究人群。平均年龄和平均 BMI 分别为 11.9 ± 3.0 岁和 18.48 ± 3.89 kg/m²。其中，2119 名（15.5%）儿童超重，536 名（3.9%）肥胖。亚临床甲状腺功能减退症在 943 名（6.9%）儿童中存在。在甲状腺功能正常的男孩和女孩中，FT3 和 TSH 水平随着 BMI 的增加而升高，FT4 水平随着 BMI 的增加而降低。与正常 BMI 儿童相比，肥胖/超重儿童的 SCH 患病率显著更高（9.0%，vs. 6.5%；P = 0.034）。
在甲状腺功能正常的学龄儿童中，血清 FT3 和 TSH 与 BMI 呈正相关，而 FT4 与 BMI 呈负相关。
