Department of Clinical Studies Veterinary Clinical Investigation Center, School of Veterinary Medicine, Philadelphia, PA 19104-6010, USA.
J Vet Intern Med. 2013 Jan-Feb;27(1):22-30. doi: 10.1111/jvim.12004.
Lameness assessment using force plate gait analysis (FPGA) and owner assessment of chronic pain using the Canine Brief Pain Inventory (CBPI) are valid and reliable methods of evaluating canine osteoarthritis. There are no studies comparing these 2 outcome measures.
Evaluate the relationship between CBPI pain severity (PS) and interference (PI) scores with the vertical forces of FPGA as efficacy measures in canine osteoarthritis.
Sixty-eight client-owned dogs with osteoarthritis (50 hind limb and 18 forelimb).
Double-blind, randomized. Owners completed the CBPI, and dogs underwent FPGA on days 0 and 14. Dogs received carprofen or placebo on days 1 through 14. The change in PS and PI scores from day 0 to 14 were compared to the change in peak vertical force (PVF) and vertical impulse (VI).
PS and PI scores significantly decreased in carprofen- compared with placebo-treated dogs (P = .002 and P = .03, respectively). PVF and VI significantly increased in carprofen- compared with placebo-treated dogs (P = .006 and P = .02, respectively). There was no correlation or concordance between the PS or PI score changes and change in PVF or VI.
In these dogs with hind limb or forelimb osteoarthritis, owner assessment of chronic pain using the CBPI and assessment of lameness using FPGA detected significant improvement in dogs treated with carprofen. The lack of correlation or concordance between the change in owner scores and vertical forces suggests that owners were focused on behaviors other than lameness when making efficacy evaluations in their dogs.
使用平板步态分析（FPGA）评估跛行和使用犬慢性疼痛简表（CBPI）评估慢性疼痛的主人评估是评估犬骨关节炎的有效且可靠的方法。目前尚无比较这两种结果测量方法的研究。
评估 CBPI 疼痛严重程度（PS）和干扰（PI）评分与 FPGA 垂直力之间的关系，作为犬骨关节炎的疗效指标。
68 只患有骨关节炎的犬（50 只后肢和 18 只前肢）。
双盲、随机。主人填写 CBPI，狗在第 0 天和第 14 天进行 FPGA。狗在第 1 天至第 14 天接受卡洛芬或安慰剂。从第 0 天到第 14 天，PS 和 PI 评分的变化与峰值垂直力（PVF）和垂直冲量（VI）的变化进行比较。
与安慰剂治疗的狗相比，卡洛芬治疗的狗的 PS 和 PI 评分显著降低（P =.002 和 P =.03）。与安慰剂治疗的狗相比，卡洛芬治疗的狗的 PVF 和 VI 显著增加（P =.006 和 P =.02）。PS 或 PI 评分变化与 PVF 或 VI 变化之间没有相关性或一致性。
在这些患有后肢或前肢骨关节炎的犬中，使用 CBPI 评估慢性疼痛的主人评估和使用 FPGA 评估跛行检测到使用卡洛芬治疗的犬有明显改善。主人评分变化与垂直力之间缺乏相关性或一致性表明，主人在对其狗进行疗效评估时，除了跛行之外，还关注其他行为。
