Laboratory of Immunobiology for Research and Diagnosis Applications (LIRAD), Blood and Tissue Bank, Germans Trias i Pujol Research Institute, Badalona, Spain.
Biomarkers. 2013 Mar;18(2):178-80. doi: 10.3109/1354750X.2012.745903. Epub 2013 Jan 11.
Celiac disease is an autoimmune disorder induced by gluten in genetically predisposed people. The discovery of new biomarkers may help in the diagnosis and follow-up of celiac patients. Regenerating islet-derived 1 alpha (REGIα)--a biomarker related to tissue regeneration--is increased in serum at the onset of the disease, decreasing after gluten-free diet (GFD). As REGIα is a 18 kDa soluble glycoprotein, it may be detected in urine samples, increasing in celiac patients. We have determined REGIα levels by ELISA. No differences were found among patients (onset or after GFD) and controls and no correlation exists among REGIα in sera and urine.
乳糜泻是一种由遗传易感性人群中的麸质引起的自身免疫性疾病。新生物标志物的发现可能有助于乳糜泻患者的诊断和随访。再生胰岛衍生 1 型（REGIα）——一种与组织再生相关的生物标志物——在疾病发作时血清中增加，在无麸质饮食（GFD）后减少。由于 REGIα 是一种 18kDa 的可溶性糖蛋白，它可能在尿样中被检测到，在乳糜泻患者中增加。我们通过 ELISA 法测定了 REGIα 水平。在患者（发病或 GFD 后）和对照组之间没有发现差异，血清和尿液中的 REGIα 之间也没有相关性。
