Buras R R, Beatty B G, Williams L E, Wanek P M, Harris J B, Hill L R, Beatty J D
Department of General Oncologic Surgery, City of Hope National Medical Center, Duarte, Calif 91010.
Arch Surg. 1990 May;125(5):660-4. doi: 10.1001/archsurg.1990.01410170108023.
Nude mice bearing subcutaneous human colon cancer xenografts (LS174T) were treated with 120 microCi of yttrium 90-labeled anti-carcinoembryonic antigen monoclonal antibodies (specific therapy), 120 microCi of 90Y-labeled anti-melanoma monoclonal antibodies (nonspecific therapy), or phosphate-buffered saline solution (no treatment control). Mean (+/- SD) tumor growth rates (percent increase per day) over the first 30 days of the study were as follows: 0.6% +/- 0.2% per day (specific therapy); 17.7% +/- 5.7% per day (nonspecific therapy); and 30.5% +/- 4.2% per day (control). In all three groups, tumors over 1 g had similar doubling times (5.74 +/- 0.71 d). Specific therapy caused a lag in tumor growth corresponding to a 3-logarithm cell kill. Estimated tumor dose of radiation obtained by tissue analysis was 34 and 14 Gy for specific and nonspecific therapy, respectively. In conclusion, 120 microCi of 90Y-labeled anti-carcinoembryonic antigen monoclonal antibodies was effective in suppressing growth of human colon cancer xenografts. Clinical studies with this preparation are recommended.
将携带人结肠癌异种移植瘤（LS174T）的裸鼠分别用120微居里的钇90标记抗癌胚抗原单克隆抗体（特异性治疗）、120微居里的90Y标记抗黑色素瘤单克隆抗体（非特异性治疗）或磷酸盐缓冲盐溶液（未治疗对照）进行处理。研究前30天的平均（±标准差）肿瘤生长速率（每天的增长率）如下：每天0.6%±0.2%（特异性治疗）；每天17.7%±5.7%（非特异性治疗）；以及每天30.5%±4.2%（对照）。在所有三组中，肿瘤重量超过1克时具有相似的倍增时间（5.74±0.71天）。特异性治疗导致肿瘤生长滞后，相当于3个对数级的细胞杀伤。通过组织分析获得的特异性和非特异性治疗的估计肿瘤辐射剂量分别为34和14戈瑞。总之，120微居里的90Y标记抗癌胚抗原单克隆抗体可有效抑制人结肠癌异种移植瘤的生长。建议对该制剂进行临床研究。
