Pulverer G, Ko H L, Roszkowski W, Beuth J, Yassin A, Jeljaszewicz J
Institut für Medizinische Mikrobiologie und Hygiene, Universität zu Köln.
Zentralbl Bakteriol. 1990 Mar;272(3):318-27. doi: 10.1016/s0934-8840(11)80034-4.
Antibiotic digestive tract decontamination in BALB/c-mice resulted in a significant reduction of peritoneal macrophage function and lymphocyte proliferation. Considerable evidence has accumulated showing that certain species of the indigenous gastrointestinal (GI)-tract microflora, e.g. Bacteroides sp., Clostridium sp., Lactobacillus sp., and Propionibacterium sp., liberate low molecular weight peptides which are able to trigger basic immune responses. Eradication of the GI-tract microflora apparently results in a lack of peptide production correlating to immunosuppression in experimental BALB/c-mice. Substitution of peptides in GI-tract decontaminated mice reconstituted macrophage function as well as proliferation of lymphatic tissue.
对BALB/c小鼠进行抗生素消化道去污处理会导致腹膜巨噬细胞功能和淋巴细胞增殖显著降低。大量证据表明，某些肠道固有微生物群落的菌种，如拟杆菌属、梭菌属、乳杆菌属和丙酸杆菌属，会释放能够引发基本免疫反应的低分子量肽。消除肠道微生物群落显然会导致与实验性BALB/c小鼠免疫抑制相关的肽生成缺乏。在经过消化道去污处理的小鼠中补充肽可恢复巨噬细胞功能以及淋巴组织的增殖。
