肠道定植在婴儿早期体液免疫成熟中的重要性：一项对0至6个月健康婴儿的前瞻性随访研究
Importance of intestinal colonisation in the maturation of humoral immunity in early infancy: a prospective follow up study of healthy infants aged 0-6 months.
作者信息
Grönlund M M, Arvilommi H, Kero P, Lehtonen O P, Isolauri E
机构信息
Department of Paediatrics, Turku University Central Hospital, Turku, Finland.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2000 Nov;83(3):F186-92. doi: 10.1136/fn.83.3.f186.
AIM
To evaluate the role of intestinal microflora and early formula feeding in the maturation of humoral immunity in healthy newborn infants.
STUDY DESIGN
Sixty four healthy infants were studied. Faecal colonisation with Bacteroides fragilis group, Bifidobacterium-like, and Lactobacillus-like bacteria was examined at 1, 2, and 6 months of age, and also the number of IgA-secreting, IgM-secreting, and IgG-secreting cells (detected by ELISPOT) at 0, 2, and 6 months of age.
RESULTS
Intestinal colonisation with bacteria from the B fragilis group was more closely associated with maturation of IgA-secreting and IgM-secreting cells than colonisation with the other bacterial genera studied or diet. Infants colonised with B fragilis at 1 month of age had more IgA-secreting and IgM-secreting cells/10(6) mononuclear cells at 2 months of age (geometric mean (95% confidence interval) 1393 (962 to 2018) and 754 (427 to 1332) respectively) than infants not colonised (1015 (826 to 1247) and 394 (304 to 511) respectively); p = 0.04 and p = 0.009 respectively.
CONCLUSIONS
The type of bacteria colonising the intestine of newborns and the timing may determine the immunomodulation of the naive immune system.
目的
评估肠道微生物群和早期配方奶喂养在健康新生儿体液免疫成熟中的作用。
研究设计
对64名健康婴儿进行研究。在1、2和6月龄时检测脆弱拟杆菌群、类双歧杆菌和类乳酸杆菌在粪便中的定植情况，同时在0、2和6月龄时检测分泌IgA、IgM和IgG的细胞数量（通过酶联免疫斑点法检测）。
结果
与所研究的其他细菌属或饮食相比，脆弱拟杆菌群细菌在肠道的定植与分泌IgA和IgM细胞的成熟更密切相关。1月龄时定植脆弱拟杆菌的婴儿在2月龄时每10⁶个单核细胞中分泌IgA和IgM的细胞更多（几何平均数（95%置信区间）分别为1393（962至2018）和754（427至1332）），而未定植的婴儿分别为1015（826至1247）和394（304至511）；p值分别为0.04和0.009。
结论
定植于新生儿肠道的细菌类型和时间可能决定幼稚免疫系统的免疫调节。
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