Nabarra B, Dardenne M, Bach J F
INSERM U25, UA 122 CNRS, Hôpital Necker, Paris, France.
J Autoimmun. 1990 Feb;3(1):25-36. doi: 10.1016/0896-8411(90)90004-c.
We examined the thymic reticulum of three strains of mice showing symptoms of lupus-like disease. Ultrastructural pathology revealed several features common to the three mouse strains in varying degrees according to sex and age of the mice. Main anomalies included vacuolized aspect of the thymic epithelium, an increased number of macrophages, interdigitating cells and cystic cavities, the presence of a great number of plasmocytes and mastocytes and extensive interstitial fibrosis and arteriosclerosis. The most intriguing finding was the presence of crystal-like inclusions in epithelial cells. Some thymuses also showed premature histologic modifications similar to those observed in the ageing involuted thymus. Dysfunction of the epithelial cell secretory system, accumulation of denatured thymic hormone as well as premature organ ageing associated with a loss of thymic function could contribute significantly to the autoimmune phenomenon observed in lupus mice.
我们检查了表现出狼疮样疾病症状的三个小鼠品系的胸腺网。超微结构病理学显示，根据小鼠的性别和年龄，这三个小鼠品系在不同程度上有几个共同特征。主要异常包括胸腺上皮的空泡化外观、巨噬细胞、交错突细胞和囊腔数量增加、大量浆细胞和肥大细胞的存在以及广泛的间质纤维化和动脉硬化。最引人注目的发现是上皮细胞中存在晶体样包涵体。一些胸腺还表现出与衰老退化胸腺中观察到的类似的过早组织学改变。上皮细胞分泌系统功能障碍、变性胸腺激素的积累以及与胸腺功能丧失相关的器官过早衰老可能对狼疮小鼠中观察到的自身免疫现象有显著影响。
