Travaux publics et Services gouvernementaux Canada, Bureau de la traduction, 70, rue Crémazie, Gatineau (Québec), Canada K1A 0S5.
Med Hypotheses. 2013 Mar;80(3):289-91. doi: 10.1016/j.mehy.2012.11.046. Epub 2013 Jan 10.
Fragile X mental retardation is caused by the absence of the FMRP (fragile X mental retardation protein) a RNA-binding protein encoded by the Fmr1 gene. Despite the large number of studies about this syndrome, it is still unclear how the absence of FMRP affects the physiology of the nervous system. It has been reported however that the brain of the Fmr1-KO mouse shows altered membrane protein and lipid oxidation. There is also indirect evidence that FMRP may be involved in a negative feedback mechanism with metabotropic glutamate receptors (mGluRs). In this article, we will discuss several lines of evidences which tend to prove that the lipoxygenase pathway might be the missing link between FMRP and mGluRs.
脆性 X 智力低下是由 FMRP（脆性 X 智力低下蛋白）缺失引起的，FMRP 是由 Fmr1 基因编码的一种 RNA 结合蛋白。尽管有大量关于这种综合征的研究，但 FMRP 的缺失如何影响神经系统的生理学仍不清楚。然而，据报道，Fmr1-KO 小鼠的大脑显示出膜蛋白和脂质氧化的改变。也有间接证据表明，FMRP 可能参与代谢型谷氨酸受体（mGluRs）的负反馈机制。在本文中，我们将讨论几条证据线，这些证据线倾向于证明脂氧合酶途径可能是 FMRP 和 mGluRs 之间缺失的联系。
