Wians F H, Strickland D M, Hankins G D, Snyder R R
Department of Pathology, Wilford Hall USAF Medical Center, Lackland AFB, Tex.
Magnes Trace Elem. 1990;9(1):28-35.
Using a pregnant goat (Capra hircus) model to study the in vivo effects of hypermagnesemia on serum osteocalcin concentration, magnesium sulfate infusion has been shown to increase circulating levels of osteocalcin. At 2 h after the administration of magnesium sulfate, a 98% increase in Mg2+ concentration over the basal level resulted in: a 38% increase in serum osteocalcin concentration over baseline; a 22% decrease in PTH concentration, and no change in total and ionized calcium concentrations. These in vivo data support previous in vitro results demonstrating that Mg2+ is a potent inhibitor of osteocalcin binding to hydroxyapatite.
利用妊娠山羊（Capra hircus）模型研究高镁血症对血清骨钙素浓度的体内影响，结果显示输注硫酸镁可使骨钙素的循环水平升高。在输注硫酸镁2小时后，Mg2+浓度较基础水平升高98%，导致血清骨钙素浓度较基线水平升高38%；甲状旁腺激素（PTH）浓度降低22%，总钙和离子钙浓度无变化。这些体内数据支持了先前的体外研究结果，即Mg2+是骨钙素与羟基磷灰石结合的有效抑制剂。
