Hankins G D, Snyder R R, Hauth J C, Gilstrap L C, Wians F H, Van Dellen A F
Department of Obstetrics and Gynecology, Wilford Hall, United States Air Force Medical Center, Lackland Air Force Base, TX 78236-5300.
Am J Perinatol. 1990 Jan;7(1):49-53. doi: 10.1055/s-2007-999446.
A comparison of standard clinical regimens for the administration of magnesium sulfate for treatment of preeclampsia was performed in the pregnant goat model. The regimen of intravenous or intramuscular load and intramuscular maintenance championed by Pritchard was found to yield higher maternal serum levels through the first 4 hours of treatment compared with intravenous load with intravenous maintenance therapy (p less than 0.05); however, neither regimen affected the concentration of magnesium ion in the cerebrospinal fluid. Urinary excretion of magnesium and passage into the amniotic fluid were also evaluated for each route of administration and neither accounted for the disparity in serum concentrations noted during the first 4 hours of magnesium therapy.
在妊娠山羊模型中对硫酸镁治疗先兆子痫的标准临床给药方案进行了比较。结果发现，与静脉负荷加静脉维持治疗相比，Pritchard倡导的静脉或肌肉负荷加肌肉维持方案在治疗的前4小时能使母体血清水平更高（p小于0.05）；然而，两种方案均未影响脑脊液中镁离子的浓度。还评估了每种给药途径的镁尿排泄及进入羊水的情况，两者均不能解释镁治疗前4小时血清浓度的差异。
