Kes P, Reiner Z
Department of Nephrology, University Hospital, Dr. M. Stojanovic, Zagreb, Yugoslavia.
Magnes Trace Elem. 1990;9(1):54-60.
Seven patients (3 females, 4 males) developed symptomatic hypomagnesemia, hypocalcemia, and hypokalemia following gentamicin therapy. The excessive and inappropriate urinary excretion of magnesium and potassium in the presence of subnormal serum concentrations was noted. A significant correlation was found between the total cumulative dose of gentamicin and serum Mg concentration (r = 0.76, p less than 0.05), as well as between the renal wasting of Mg and the total cumulative dose of gentamicin administered (r = 0.89, p less than 0.01). The gentamicin-induced Mg depletion is a very rare but important complication which is most likely to occur when the drug is given to older patients in large doses over extended periods of time.
7例患者（3例女性，4例男性）在庆大霉素治疗后出现症状性低镁血症、低钙血症和低钾血症。在血清浓度低于正常的情况下，发现镁和钾的尿排泄过多且不适当。庆大霉素的总累积剂量与血清镁浓度之间存在显著相关性（r = 0.76，p < 0.05），以及镁的肾脏丢失与给予的庆大霉素总累积剂量之间也存在显著相关性（r = 0.89，p < 0.01）。庆大霉素引起的镁缺乏是一种非常罕见但重要的并发症，当该药物长时间大剂量给予老年患者时最有可能发生。
