Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain; Department of Psychiatry, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IP), Universidad Autónoma de Madrid, Spain.
Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 1):2372-4. doi: 10.1016/j.neubiorev.2013.01.008. Epub 2013 Jan 11.
The social and economic impact of mood disorders and suicide is extremely high and may be even higher in coming years, and yet, research in mental health is largely underfunded. This report summarizes the most recent data concerning the epidemiology and burden of depression and suicide, and underlines the most recent initiatives to identify the barriers to effective treatment and prevention of mood disorders. Global cooperation and networks of research networks are proposed. Progress in the understanding of the pathophysiology and subtypes of depression, technological advances, emphasis on early prediction of response and prevention, and a paradigm shift in drug development are crucial to overcome the current challenges posed by increasing rates of depression and suicide.
心境障碍和自杀的社会经济影响极其巨大，而且在未来几年可能会更高，然而，精神健康领域的研究却严重资金不足。本报告总结了关于抑郁症和自杀的最新流行病学和负担数据，并强调了为确定有效治疗和预防心境障碍的障碍而采取的最新举措。提出了全球合作和研究网络的建议。在理解抑郁症的病理生理学和亚型、技术进步、强调早期预测反应和预防，以及药物开发范式转变方面取得进展，对于克服当前因抑郁症和自杀率上升而带来的挑战至关重要。
