Nakano K, Miyamoto A, Imai K, Mochizuki Y, Hayashi K, Mitsuishi Y, Fukuyama Y, Kohno A, Shigeta T
Department of Pediatrics, Tokyo Women's Medical College.
No To Hattatsu. 1990 Mar;22(2):173-8.
We studied the 3rd lumbar vertebral trabecular bone mineral density in 59 cross-sectional pictures of quantitative computed tomography (QCT) with CaCO3 phantom for 28 hospital control children and 30 cases of suspected bone metabolic disorders. The QCT value of bone mineral density of control children showed neither age dependency nor sexual difference before puberty: for males was 221.8 +/- 30.2 mg CaCO3/cm3 (Mean +/- SD) under 4 years, 218.1 +/- 39.7 at 5-9 years and 217.2 +/- 30.9 at 10-15 years; and for females 220.9 +/- 18.3 under 4 years and 240.0 +/- 29.4 at 5-9 years. The QCT values of bone mineral density in bed-ridden patients, children receiving glucocorticoids and children receiving anticonvulsants were significantly lower than that in control children (p less than 0.005). The QCT value of bone mineral density of bed-ridden patients was significantly lower than that of children receiving glucocorticoids and of children receiving anticonvulsants (p less than 0.05, p less than 0.005 respectively). Our study confirmed that single energy quantitative CT was very useful in pediatric clinical application.
我们利用碳酸钙体模，通过59张定量计算机断层扫描（QCT）横断面图像，对28名医院对照儿童和30例疑似骨代谢紊乱患儿的第三腰椎小梁骨矿物质密度进行了研究。对照儿童骨矿物质密度的QCT值在青春期前既无年龄依赖性也无性别差异：4岁以下男性为221.8±30.2mg碳酸钙/cm³（均值±标准差），5 - 9岁为218.1±39.7，10 - 15岁为217.2±30.9；4岁以下女性为220.9±18.3，5 - 9岁为240.0±29.4。卧床患者、接受糖皮质激素治疗的儿童以及接受抗惊厥药物治疗的儿童的骨矿物质密度QCT值显著低于对照儿童（p<0.005）。卧床患者的骨矿物质密度QCT值显著低于接受糖皮质激素治疗的儿童和接受抗惊厥药物治疗的儿童（分别为p<0.05，p<0.005）。我们的研究证实，单能量定量CT在儿科临床应用中非常有用。
