Neuropsychophysiology Laboratory, CIPsi, School of Psychology, University of Minho, Braga, Portugal.
Alzheimer Dis Assoc Disord. 2013 Jul-Sep;27(3):195-203. doi: 10.1097/WAD.0b013e31827bda55.
Several studies have shown that cognitive intervention may be beneficial for people with Alzheimer disease (AD), but literature reviews conducted so far, have yielded mixed and inconclusive results. In this work, through an extensive bibliographic search, we aim: (1) to analyze the efficacy of cognitive intervention in patients diagnosed with AD; (2) to provide an estimate of the feasibility of cognitive intervention; and (3) to review available cost-effectiveness data of this approach. Four randomized controlled trials of cognitive intervention, for patients diagnosed with AD that incorporated cognitive intervention and mock intervention control conditions, were included in the analysis. Only the domain of global cognitive functioning, as measured by Mini-Mental State Examination, showed significant intervention effects. No effects were observed in the remaining domains. Concerning feasibility, high rates of completion and adherence were found. A single randomized controlled trial, with unspecified dementia, suggested cognitive intervention to be cost-effective. Given the currently available dearth of well-controlled and focused trials in AD, these results should be carefully interpreted and remain to be confirmed in the future. There is a clear need for more high-quality research.
几项研究表明，认知干预可能对阿尔茨海默病（AD）患者有益，但迄今为止进行的文献综述得出的结果喜忧参半，不一致。在这项工作中，我们通过广泛的文献检索，旨在：（1）分析认知干预对 AD 患者的疗效；（2）提供认知干预可行性的估计；（3）回顾该方法的现有成本效益数据。分析中纳入了四项针对 AD 患者的认知干预随机对照试验，这些试验纳入了认知干预和模拟干预对照组。只有通过简易精神状态检查（Mini-Mental State Examination）测量的整体认知功能这一领域显示出显著的干预效果。其余领域均未观察到效果。关于可行性，发现完成率和依从率很高。一项针对特定痴呆症的随机对照试验表明，认知干预具有成本效益。鉴于目前 AD 领域缺乏精心控制和针对性的试验，这些结果应谨慎解读，并有待未来进一步证实。显然需要进行更多高质量的研究。
