Lasaponara Stefano, Marson Fabio, Doricchi Fabrizio, Cavallo Marco
Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy.
Department of Human Sciences, LUMSA University, 00193 Rome, Italy.
Brain Sci. 2021 Apr 21;11(5):528. doi: 10.3390/brainsci11050528.
Most prevalent neurodegenerative diseases such as Alzheimer's disease, frontotemporal dementia, Parkinson's disease and multiple sclerosis are heterogeneous in their clinical profiles and underlying pathophysiology, although they typically share the presence of cognitive impairment that worsens significantly during the course of the disease. Viable pharmacological options for cognitive symptoms in these clinical conditions are currently lacking. In recent years, several studies have started to apply Computerized Cognitive Training (CCT) and Virtual Reality (VR) tools to try and contrast patients' cognitive decay over time. However, no in-depth literature review of the contribution of these promising therapeutic options across main neurodegenerative diseases has been conducted yet. The present paper reports the state-of-the-art of CCT and VR studies targeting cognitive impairment in most common neurodegenerative conditions. Our twofold aim is to point out the scientific evidence available so far and to support health professionals to consider these promising therapeutic tools when planning rehabilitative interventions, especially when the access to regular and frequent hospital consultations is not easy to be provided.
大多数常见的神经退行性疾病，如阿尔茨海默病、额颞叶痴呆、帕金森病和多发性硬化症，在临床特征和潜在病理生理学方面存在异质性，尽管它们通常都存在认知障碍，且在疾病过程中会显著恶化。目前，针对这些临床病症中认知症状的可行药物选择尚不存在。近年来，多项研究已开始应用计算机化认知训练（CCT）和虚拟现实（VR）工具，试图对抗患者随时间推移出现的认知衰退。然而，尚未对这些有前景的治疗选择在主要神经退行性疾病中的作用进行深入的文献综述。本文报告了针对最常见神经退行性疾病中认知障碍的CCT和VR研究的最新进展。我们的双重目标是指出目前可用的科学证据，并支持医疗专业人员在规划康复干预措施时考虑这些有前景的治疗工具，特别是在难以提供定期且频繁的医院会诊的情况下。
