*Faculty of Psychology and Educational Sciences †Psychological Assessment Lab, CINEICC, Faculty of Psychology and Educational Sciences ‡Department of Languages, Literatures and Cultures, Center of General and Applied Linguistics §Department of Neurology, Coimbra University Hospital and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Alzheimer Dis Assoc Disord. 2013 Oct-Dec;27(4):324-9. doi: 10.1097/WAD.0b013e31827bdc8c.
APA guidelines for the evaluation of age-related cognitive decline and dementia emphasize the need for baseline (premorbid) data against which current performance can be compared. As this information rarely exists, clinicians must rely on instruments especially designed for estimation of premorbid abilities. No such instrument was available in Portugal until the development of the TeLPI, an irregular words oral reading test. This study aims to examine TeLPI's validity as a measure of premorbid ability in the spectrum of aging cognitive decline, from mild cognitive impairment (MCI) to moderate Alzheimer disease (AD), by the analysis of its stability in normal versus impaired samples. A total of 104 patients, classified into 2 clinical groups, MCI (n=53) and probable mild to moderate AD (n=51), were compared with a group of cognitively healthy controls (C_MCI: n=53; C_AD: n=51) and matched for sex, age, education, and residence. As expected, the Mini-Mental State Examination and Montreal Cognitive Assessment results were significantly different between the groups (AD<MCI<controls), reflecting the severity of cognitive impairment. TeLPI median scores of controls, MCI, and probable AD patients were comparable after correcting for years of education, revealing no significant effect of cognitive impairment on TeLPI performance, and suggesting its validity for estimating premorbid intelligence in subjects with cognitive decline and dementia.
APA 指南强调了需要对与当前表现进行比较的基线（发病前）数据进行评估，以评估与年龄相关的认知能力下降和痴呆。由于这种信息很少存在，临床医生必须依赖专门用于估计发病前能力的工具。直到葡萄牙开发了不规则单词口语阅读测试 TeLPI，才出现了这种工具。本研究旨在通过分析正常与受损样本中的稳定性，检查 TeLPI 作为从轻度认知障碍（MCI）到中度阿尔茨海默病（AD）的衰老认知下降范围内的发病前能力的测量的有效性。共有 104 名患者，分为 2 个临床组，MCI（n=53）和可能的轻度至中度 AD（n=51），与认知健康对照组（C_MCI：n=53；C_AD：n=51）进行了比较，并且按照性别、年龄、教育程度和居住地进行了匹配。正如预期的那样，简易精神状态检查和蒙特利尔认知评估的结果在组间存在显著差异（AD<MCI<对照组），反映了认知障碍的严重程度。在纠正了受教育年限后，对照组、MCI 和可能的 AD 患者的 TeLPI 中位数得分相当，表明认知障碍对 TeLPI 表现没有显著影响，表明其对估计认知能力下降和痴呆患者的发病前智力具有有效性。
