Yi Dahyun, Seo Eun Hyun, Han Ji Young, Sohn Bo Kyung, Byun Min Soo, Lee Jun Ho, Choe Young Min, Ahn Suzy, Woo Jong Inn, Jun Jongho, Lee Dong Young
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
Premedical Science, College of Medicine, Chosun University, Gwangju, South Korea.
PLoS One. 2017 Jul 19;12(7):e0181523. doi: 10.1371/journal.pone.0181523. eCollection 2017.
We aimed to develop a word-reading test for Korean-speaking adults using irregularly pronounced words that would be useful for estimation of premorbid intelligence. A linguist who specialized in Korean phonology selected 94 words that have irregular relationship between orthography and phonology. Sixty cognitively normal elderly (CN) and 31 patients with Alzheimer's disease (AD) were asked to read out loud the words and were administered the Wechsler Adult Intelligence Scale, 4th edition, Korean version (K-WAIS-IV). Among the 94 words, 50 words that did not show a significant difference between the CN and the AD group were selected and constituted the KART. Using the 30 CN calculation group (CNc), a linear regression equation was obtained in which the observed full-scale IQ (FSIQ) was regressed on the reading errors of the KART, where education was included as an additional variable. When the regressed equation computed from the CNc was applied to 30 CN individuals of the validation group (CNv), the predicted FSIQ adequately fit the observed FSIQ (R2 = 0.63). In addition, independent sample t-test showed that the KART-predicted IQs were not significantly different between the CNv and AD groups, whereas the performance of the AD group was significantly worse in the observed IQs. In addition, an extended validation of the KART was performed with a separate sample consisted of 84 CN, 56 elderly with mild cognitive impairment (MCI), and 43 AD patients who were administered comprehensive neuropsychological assessments in addition to the KART. When the equation obtained from the CNc was applied to the extended validation sample, the KART-predicted IQs of the AD, MCI and the CN groups did not significantly differ, whereas their current global cognition scores significantly differed between the groups. In conclusion, the results support the validity of KART-predicted IQ as an index of premorbid IQ in individuals with AD.
我们旨在为说韩语的成年人开发一种单词阅读测试，使用发音不规则的单词，这将有助于评估病前智力。一位专门研究韩语语音学的语言学家选择了94个在拼字法和语音学之间具有不规则关系的单词。60名认知正常的老年人（CN）和31名阿尔茨海默病（AD）患者被要求大声朗读这些单词，并接受韦氏成人智力量表第四版韩语版（K-WAIS-IV）测试。在这94个单词中，选择了50个在CN组和AD组之间没有显著差异的单词，组成了KART。使用30名CN计算组（CNc），得到了一个线性回归方程，其中观察到的全量表智商（FSIQ）基于KART的阅读错误进行回归，并将教育程度作为一个额外变量纳入。当将从CNc计算出的回归方程应用于验证组（CNv）的30名CN个体时，预测的FSIQ与观察到的FSIQ充分拟合（R2 = 0.63）。此外，独立样本t检验表明，CNv组和AD组之间KART预测的智商没有显著差异，而AD组在观察到的智商方面表现明显更差。此外，使用一个单独的样本对KART进行了扩展验证，该样本包括84名CN、56名轻度认知障碍（MCI）老年人和43名AD患者，除了KART外，他们还接受了全面的神经心理学评估。当将从CNc获得的方程应用于扩展验证样本时，AD组、MCI组和CN组的KART预测智商没有显著差异，而他们当前的整体认知分数在组间有显著差异。总之，结果支持KART预测智商作为AD个体病前智商指标的有效性。
