Axe Jeremie M, Snyder-Mackler Lynn, Axe Michael J
Tufts Medical Center, Boston, MA 02111, USA.
Sports Med Arthrosc Rev. 2013 Mar;21(1):18-22. doi: 10.1097/JSA.0b013e3182673241.
The treatment of early osteoarthritis in middle-aged athletes with intra-articular (IA) viscosupplementation using hyaluronic acid (HA) has been used since the late 1980s. Administration of IA HA has demonstrated anti-inflammatory, anabolic, and analgesic effects. Treatment of acute injuries such as anterior cruciate ligament reconstruction and full thickness chondral lesions have benefited with the addition of IA HA. Use of IA HA has also been shown to delay total knee arthroplasty. Although IA HA has shown significant benefits in the middle-aged athletes, it is not a ubiquitous treatment option. Success with corticosteroid injections can be used as a clinical marker for subsequent success with HA injections.
自20世纪80年代末以来，使用透明质酸（HA）进行关节内（IA）粘弹性补充疗法一直用于治疗中年运动员的早期骨关节炎。关节内注射HA已显示出抗炎、促合成代谢和镇痛作用。在前交叉韧带重建和全层软骨损伤等急性损伤的治疗中，添加关节内注射HA已取得了良好效果。使用关节内注射HA还被证明可延迟全膝关节置换术。尽管关节内注射HA在中年运动员中已显示出显著益处，但它并非普遍适用的治疗选择。皮质类固醇注射的成功可作为后续HA注射成功的临床指标。
