Division of Neonatology and Program in Pediatric Molecular and Personalized Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Pediatr Res. 2013 Apr;73(4 Pt 2):514-22. doi: 10.1038/pr.2013.7. Epub 2013 Jan 11.
A greater understanding of the regulatory processes contributing to lung development could be helpful to identify strategies to ameliorate morbidity and mortality in premature infants and to identify individuals at risk for congenital and/or chronic lung diseases. Over the past decade, genomics technologies have enabled the production of rich gene expression databases providing information for all genes across developmental time or in diseased tissue. These data sets facilitate systems biology approaches for identifying underlying biological modules and programs contributing to the complex processes of normal development and those that may be associated with disease states. The next decade will undoubtedly see rapid and significant advances in redefining both lung development and disease at the systems level.
对促进肺发育的调控过程有更深入的了解，有助于确定改善早产儿发病率和死亡率的策略，并识别患有先天性和/或慢性肺部疾病的高危个体。在过去的十年中，基因组学技术产生了丰富的基因表达数据库，为整个发育过程或病变组织中的所有基因提供了信息。这些数据集促进了系统生物学方法的应用，有助于识别导致正常发育的复杂过程以及可能与疾病状态相关的潜在生物学模块和程序。毫无疑问，在系统水平上重新定义肺发育和疾病的下一个十年将取得快速而重大的进展。
