Department of Digestive Surgery, Nihon University School of Medicine, 30-1 Ohyaguchi Kamimachi, Itabashi-Ku, Tokyo 173-8610, Japan.
Cancer Chemother Pharmacol. 2013 Mar;71(3):727-31. doi: 10.1007/s00280-012-2066-9. Epub 2013 Jan 12.
The purpose of this study was to investigate whether intravenous (i.v.) administration allowed docetaxel to penetrate ascites in gastric cancer patients with peritoneal dissemination.
Twelve patients with disseminated gastric carcinoma were enrolled in the study. All patients received docetaxel-containing drug regimens: i.v. administration of 40 mg/m(2) docetaxel in 6 patients, and 60 mg/m(2) in the remainder. Docetaxel concentrations in the plasma and ascites were measured.
Docetaxel was detected in the ascites of 4 patients in the 40 mg/m(2) group and 5 patients in the 60 mg/m(2) group. The highest concentration of docetaxel in plasma was detected at immediately after administration (median: 1,660 ng/mL, 501-2,560 ng/mL), after which it gradually decreased. The highest concentration of docetaxel in ascites was observed at ~7 h after administration and varied among cases (median: 18 ng/mL, 11-52 ng/mL).
Intravenous administration allows to penetrate ascites in gastric cancer patients with peritoneal dissemination.
本研究旨在探讨静脉（iv）给药是否能使紫杉醇进入伴有腹膜扩散的胃癌患者的腹水。
本研究纳入了 12 例患有弥漫性胃癌的患者。所有患者均接受了含紫杉醇的药物治疗方案：6 例患者静脉给予 40mg/m²紫杉醇，其余患者给予 60mg/m²紫杉醇。检测了血浆和腹水中的紫杉醇浓度。
40mg/m²组的 4 例患者和 60mg/m²组的 5 例患者的腹水中检测到了紫杉醇。紫杉醇在血浆中的最高浓度在给药后立即检测到（中位数：1660ng/mL，501-2560ng/mL），之后逐渐下降。腹水中紫杉醇的最高浓度在给药后约 7 小时观察到，且各病例之间存在差异（中位数：18ng/mL，11-52ng/mL）。
静脉给药可使紫杉醇渗透到伴有腹膜扩散的胃癌患者的腹水中。
