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毛囊黑素细胞作为用于培养和移植的黑素细胞的可再生来源。

Hair follicle melanocyte cells as a renewable source of melanocytes for culture and transplantation.

作者信息

Kwon Ho, Liu Perry H, Lew Dae-Hyun, Nishimura Emi, Orgill Dennis P

机构信息

Tissue Engineering and Wound Healing Laboratory, Division of Plastic & Reconstructive Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

出版信息

Eplasty. 2008;8:e7. Epub 2008 Jan 9.

PMID:23314700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2205995/
Abstract

OBJECTIVE

Advances in melanocyte culture techniques have not yet led to reliable clinical methods for treating hypopigmentation disorders. We hypothesized that melanocytes harvested from plucked hair follicles may provide a renewable source of melanocytes for the treatment of hypopigmentation.

METHODS

Hairs with attached cells from the follicles were plucked from Yucatan pigs and implanted in a collagen-glycosaminoglycan matrix for either immediate or delayed implantation into full-thickness excisional porcine wounds. Wounds were allowed to heal and were biopsied at 2 and 4 weeks, respectively.

RESULTS

Fully healed wounds with transplanted hair follicles showed central areas of dark pigmentation corresponding to the location of implanted hair follicles. Corresponding collagen-glycosaminoglycan matrix wounds showed no central areas of pigmentation.

CONCLUSIONS

Hair follicle--derived melanocytes may potentially serve as a renewable source of pigment-producing cells for treating hypopigmentation disorders.

摘要

目的

黑素细胞培养技术的进展尚未带来治疗色素减退性疾病的可靠临床方法。我们推测，从拔除的毛囊中获取的黑素细胞可能为色素减退的治疗提供可再生的黑素细胞来源。

方法

从尤卡坦猪身上拔除带有毛囊附着细胞的毛发，并植入胶原-糖胺聚糖基质中，以便立即或延迟植入猪的全层切除伤口。让伤口愈合，并分别在第2周和第4周进行活检。

结果

移植毛囊的完全愈合伤口显示出与植入毛囊位置相对应的中央深色色素沉着区域。相应的胶原-糖胺聚糖基质伤口未显示中央色素沉着区域。

结论

毛囊来源的黑素细胞可能潜在地作为治疗色素减退性疾病的色素生成细胞的可再生来源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/0727cbbc0413/eplasty08e7_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/ba84a9e1b0ba/eplasty08e7_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/48694bd1e972/eplasty08e7_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/15c4493886d4/eplasty08e7_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/8c1d634ff065/eplasty08e7_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/e11d9d00d65e/eplasty08e7_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/72068ad3adb3/eplasty08e7_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/0727cbbc0413/eplasty08e7_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/ba84a9e1b0ba/eplasty08e7_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/48694bd1e972/eplasty08e7_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/15c4493886d4/eplasty08e7_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/8c1d634ff065/eplasty08e7_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/e11d9d00d65e/eplasty08e7_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/72068ad3adb3/eplasty08e7_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171b/2205995/0727cbbc0413/eplasty08e7_fig7.jpg

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