Logan Beth A, Brown Mark S, Hayes Marie J
Graduate School of Biomedical Sciences and Department of Psychology, University of Maine, Orono, ME, USA.
Clin Obstet Gynecol. 2013 Mar;56(1):186-92. doi: 10.1097/GRF.0b013e31827feea4.
Recent rise in rates of opiate replacement therapy among pregnant women have resulted in increasing number of infants requiring treatment for neonatal abstinence syndrome (NAS). Short-term and long-term developmental outcomes associated with prenatal opiate exposure are discussed, including symptoms and severity of NAS, and early cognitive and motor delays. Maternal and infant risk factors are discussed, and include patterns of maternal substance use during pregnancy, genetic risk, polysubstance exposure pharmacological treatment for NAS and breastfeeding. The importance of characterizing corollary environmental risk factors is also considered.
近期孕妇阿片类药物替代疗法使用率的上升，导致需要治疗新生儿戒断综合征（NAS）的婴儿数量不断增加。本文讨论了与产前阿片类药物暴露相关的短期和长期发育结果，包括NAS的症状和严重程度，以及早期认知和运动发育迟缓。还讨论了母婴风险因素，包括孕期母亲物质使用模式、遗传风险、多物质暴露、NAS的药物治疗以及母乳喂养。同时也考虑了描述相关环境风险因素的重要性。
